Browse the latest research summaries in the field of aging for spinal cord injury patients and caregivers.
Showing 11-20 of 150 results
Scientific Reports, 2023 • May 5, 2023
This study assessed the incremental prognostic value of the modified frailty index-5 (mFI-5) over age in predicting in-hospital mortality among patients with complete traumatic cervical spinal cord in...
KEY FINDING: Both age and mFI-5 had statistically significant associations with in-hospital mortality.
Journal of Patient-Reported Outcomes, 2023 • June 4, 2023
This COSMIN systematic review evaluated falls-risk perception measures in an inpatient setting. The review categorized 20 PROMs according to five fall-related constructs and found that only two PROMs ...
KEY FINDING: Two PROMs received Class A recommendations: the Falls Risk Perception Questionnaire (FRPQ) and the Spinal Cord Injury-Falls Concern Scale (SCI-FCS).
Cellular & Molecular Biology Letters, 2023 • September 7, 2023
This study investigates the role of astrocyte senescence in neuroinflammation and neuropathic pain (NeP) following peripheral nerve injury (PNI). The findings suggest that PNI induces a senescence-lik...
KEY FINDING: Sciatic nerve CCI in rats resulted in reduced paw mechanical withdrawal threshold (PMWT) and paw thermal withdrawal latency (PTWL), indicating pain hypersensitivity.
Healthcare, 2023 • August 10, 2023
This case report describes purple urine bag syndrome (PUBS) in an elderly woman with several predisposing factors, including immobility, long-term catheterization, and constipation. The syndrome is ca...
KEY FINDING: A 79-year-old home-dwelling female with a history of immobility due to a spinal fracture, long-term catheterization, and constipation developed purple urine bag syndrome.
GeroScience, 2024 • October 25, 2023
This study used the NIH Toolbox Motor Battery (NIHTBm) as an objective measure to determine DCM severity by defining NIHTBm cutoff values that can accurately classify the severity of DCM neuromotor dy...
KEY FINDING: Specific NIHTBm cutoff values were identified for classifying DCM severity based on motor assessments.
J. Clin. Med., 2023 • November 11, 2023
This retrospective study analyzed data from the German Pelvis Registry between 2008 and 2017, focusing on acetabular fractures in patients over and under 65 years old. The study aimed to determine if ...
KEY FINDING: The complication rate of the geriatric group was twice as high as that of younger patients; however, this finding was independent of the timing of surgery.
PLOS ONE, 2024 • May 16, 2024
This study analyzed data from 1152 patients with traumatic spinal cord injuries (TSCI) in Japan over a 15-year period (2005-2021). The study found a significant increase in the average age of TSCI pat...
KEY FINDING: There was a statistically significant increasing trend in age at injury. Since 2014, the average age of injury has increased to exceed 60 years.
Bone Research, 2024 • February 19, 2024
This study demonstrates microvascular endothelial cell senescence induced by spinal cord injury (SCI). Lysine demethylase 6A (Kdm6a), commonly known as UTX, emerges as a crucial regulator of cell sene...
KEY FINDING: Spinal cord injury (SCI) induces senescence in spinal cord microvascular endothelial cells (SCMECs).
Human Brain Mapping, 2024 • June 10, 2024
The study aimed to develop and validate a pre-trained brain-age model covering most of the human lifespan, addressing the need for robust and publicly available models. Researchers systematically exam...
KEY FINDING: The accuracy of age prediction was higher when no site harmonization (correction for differences between data collection sites) was applied to the brain imaging data.
Oxidative Medicine and Cellular Longevity, 2021 • September 1, 2021
This study investigates the role of mitochondrial ROS in mechanical stress-induced disc degeneration using a one-strike loading organ culture model. The researchers found that mechanical stress leads ...
KEY FINDING: Mechanical stress induces mitochondrial dysfunction and ROS accumulation in nucleus pulposus (NP) cells. The proportion of ROS-positive cells increased significantly in the first 12 hours after mechanical stress.