Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 3,891-3,900 of 12,052 results
Neural Regeneration Research, 2023 • October 11, 2022
This study investigates the effect of ginsenoside Rb1 (G-Rb1) on energy metabolism in spinal cord injury (SCI) using mouse and cell models. The results demonstrate that G-Rb1 inhibits neuronal oxidati...
KEY FINDING: Ginsenoside Rb1 (G-Rb1) inhibits neuronal oxidative stress, protects mitochondria, promotes neuronal metabolic reprogramming, and increases glycolytic activity and ATP production.
Neural Regeneration Research, 2023 • October 11, 2022
This study investigates the role of thrombin in regulating cholesterol metabolism in astrocytes following spinal cord injury (SCI) in rats. The results demonstrate that SCI-induced thrombin activation...
KEY FINDING: Spinal cord injury increases thrombin and CH25H expression in rat astrocytes.
Neural Regeneration Research, 2023 • October 11, 2022
This study explored the protective role of PARP14 in SCI, finding that PARP14 expression increases at the injury site in a mouse model of SCI, and its knockdown worsens SCI. Both in vivo and in vitro ...
KEY FINDING: PARP14 expression is upregulated in spinal cord tissues after SCI, suggesting a compensatory mechanism.
Bone Research, 2022 • October 11, 2022
This study investigates the cellular origin of neurogenic heterotopic ossifications (NHOs), which frequently develop in muscles after spinal cord injuries (SCIs). Using lineage-tracing experiments in ...
KEY FINDING: NHOs developing after SCI in injured muscles in mice are not derived from muscle SCs. We also reveal that NHOs only develop in areas of the injured muscle where SCs fail to regenerate myofibers.
Oxidative Medicine and Cellular Longevity, 2022 • October 11, 2022
This study used bioinformatics analysis to identify genes associated with mitochondrial dysfunction in intervertebral disc degeneration (IDD). Datasets GSE70362 and GSE124272 were downloaded from the ...
KEY FINDING: Identified 152 differentially expressed genes (DEGs) between IDD patients and healthy controls, including 67 upregulated and 85 downregulated genes.
Frontiers in Neuroscience, 2022 • October 10, 2022
This study investigates the therapeutic effects of astaxanthin (AST) and folic acid (FC) on brachial plexus avulsion (BPA) in rats. The combination of AST and FC showed a synergistic effect due to AST...
KEY FINDING: AST-FC combined therapy effectively alleviated oxidative stress and the inflammatory response in the acute phase of BPA.
Neural Regeneration Research, 2023 • October 10, 2022
This review summarizes the regulatory role of Chx10-expressing V2a spinal interneurons in spinal locomotion and spinal cord disease, noting their origin in the p2 progenitor domain and induction by No...
KEY FINDING: Chx10+V2a interneurons originate from the p2 progenitor domain and are directed by Notch and TGF-β signals, which suppress motoneuron fates, ensuring the appropriate balance of V2a/V2b commitment through transcription factors.
Frontiers in Molecular Neuroscience, 2022 • October 10, 2022
This editorial introduces a Research Topic focusing on biochemical and genetic tools to investigate and treat sensorimotor pathologies, particularly those resulting from spinal cord injury (SCI) and o...
KEY FINDING: Mitochondrial lesions outside the injury area and downregulation of enzymes essential for the TCA cycle and amino acid metabolism occur after SCI, but could be partially reversed by thiamine administration, leading to improved locomotor performance.
Frontiers in Surgery, 2022 • October 10, 2022
This multicenter retrospective study analyzed 2,621 patients with traumatic spinal cord injuries (TSCIs) in northwest China from 2017 to 2020 to understand epidemiological characteristics and risk fac...
KEY FINDING: The number of patients with TSCI showed an increasing trend from 2017 to 2019, while there were 12.8% fewer patients in 2020 than in 2019.
Neural Regeneration Research, 2023 • October 10, 2022
The study investigated the effect of double-target NC-MS on rats with incomplete SCI, finding that it improved motor function and promoted recovery of the descending motor pathway. NC-MS treatment att...
KEY FINDING: Double-target NC-MS treatment improved motor function in rats with incomplete SCI, as evidenced by increased BBB scores and inclined-plane angles.