Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,481-11,490 of 12,052 results
Neurosci Lett, 2010 • September 6, 2010
This study demonstrates that GsMTx4, a mechanosensitive ion channel inhibitor, potentiates neurite outgrowth in PC12 cells when combined with NGF. The peptide's effect is dose-dependent and requires e...
KEY FINDING: GsMTx4, a peptide inhibitor of mechanosensitive ion channels, enhances neurite outgrowth from PC12 cells in the presence of NGF in a dose-dependent manner.
The Journal of Clinical Investigation, 2010 • September 1, 2010
This commentary discusses a study by Abematsu et al. on neural stem cell transplantation in a mouse model of spinal cord injury (SCI). The study demonstrates that transplanted neural stem cells, when ...
KEY FINDING: Neural stem cell transplantation can reconstruct spinal neuronal circuits in mice with severe spinal cord injury.
Nat Neurosci, 2010 • September 1, 2010
This study investigates the role of PTEN/mTOR in controlling the regenerative capacity of mouse corticospinal neurons after spinal cord injury. The researchers found that forced up-regulation of mTOR ...
KEY FINDING: Deleting PTEN in adult corticospinal neurons enhances compensatory sprouting of uninjured CST axons.
Exp Neurol, 2010 • September 1, 2010
This study investigated the use of peripheral nerve grafts (PNG) combined with chondroitinase ABC (ChABC) to promote axon regeneration after incomplete cervical spinal cord injury (SCI) in adult cats....
KEY FINDING: The peripheral nerve grafts survived in most animals, and thousands of myelinated axons were found within each graft.
Spinal Cord, 2010 • September 1, 2010
This study described self-identified indoor and outdoor participation outcomes in conjunction with satisfaction ratings with performance of the outcomes among community dwelling people with SCI. Parti...
KEY FINDING: Community dwelling people with SCI commonly engage in wheelchair oriented participation outcomes related to “community, social, and civil life”, “domestic life”, and “mobility”.
The Journal of Neuroscience, 2010 • August 25, 2010
This study challenges the long-standing controversy about whether spinal cord injury (SCI) causes retrograde cell death of corticospinal tract (CST) neurons. By directly assessing CST axons in the med...
KEY FINDING: Only a small fraction of axons in the medullary pyramid showed signs of degeneration after SCI, comparable to uninjured rats.
Journal of NeuroEngineering and Rehabilitation, 2010 • August 20, 2010
This study aimed to compare kinematic data of upper limb movements during a drinking task among individuals with C6 tetraplegia, C7 tetraplegia, and a control group. The results indicated that individ...
KEY FINDING: Subjects with C6 tetraplegia performed the drinking task at a slower velocity and with more prolonged phases compared to the control group.
CELLULAR & MOLECULAR BIOLOGY LETTERS, 2010 • August 14, 2010
The study cloned GFAP cDNA from Gekko japonicus and examined its expression changes after spinal cord transection. GFAP expression increased and then decreased after spinal cord injury (SCI), predomin...
KEY FINDING: GFAP expression in the spinal cord increased after transection, peaking at 3 days, then gradually decreasing.
The Journal of Neuroscience, 2010 • August 11, 2010
This study investigates the potential of genetically attenuating myelin and Semaphorin-mediated inhibition to promote axon regeneration after spinal cord injury. The research focused on serotonergic a...
KEY FINDING: Deleting Nogo, MAG, and NgR1 (three myelin inhibitors) did not enhance serotonergic axon regeneration after complete spinal cord transection.
The Journal of Neuroscience, 2010 • August 11, 2010
This study compared fixed-trajectory and assist-as-needed (AAN) robotic training paradigms in spinal cord transected rats to understand the role of variability in spinal learning. The AAN paradigm, wh...
KEY FINDING: The assist-as-needed (AAN) training paradigm resulted in more normal flexor-extensor activation patterns compared to the fixed-trajectory paradigm in spinal cord transected rats.