Browse the latest research summaries in the field of veterinary medicine for spinal cord injury patients and caregivers.
Showing 71-80 of 90 results
Korean J Neurotrauma, 2014 • March 17, 2014
This study describes a method for inducing spinal cord injuries in dogs by using balloon catheters via laminectomy and the subsequent changes in the electrophysiological response. The results of this ...
KEY FINDING: Open field testing yielded locomotor scores of 0 or 1 for dogs subjected to compression for 3 days, with no obvious improvement and flaccid tonus in hindlimbs.
Vet. Sci., 2021 • November 23, 2021
This study investigated the effectiveness of predegenerated nerve grafts in improving locomotor function in spinal cord-injured monkeys. Monkeys were trained to perform bipedal locomotion on complex r...
KEY FINDING: All operated monkeys showed significant deficits in locomotion on runways at the early postoperative period.
Journal of Tissue Engineering and Regenerative Medicine, 2022 • May 24, 2022
This study investigated the safety and feasibility of transplanting hydrogel-encapsulated autologous olfactory ensheathing cells (mOECs) expressing chondroitinase ABC (chABC) into the spinal cords of ...
KEY FINDING: The intraspinal transplantation of hydrogel‐encapsulated autologous mucosal olfactory ensheathing cell (mOEC) populations expressing chondroitinase ABC (chABC) is feasible and safe in paraplegic dogs in a clinical setting.
Stem Cell Research & Therapy, 2023 • January 4, 2023
This study evaluated the therapeutic potential of autogenic Low laser-activated SVF transplantation in the functional recovery and structural remodeling in the ethidium bromide-induced MS in cats. SVF...
KEY FINDING: Pelvic limb locomotion significantly recovered in the SVF co-treated group (Group III).
Frontiers in Veterinary Science, 2023 • July 13, 2023
This study evaluated the efficacy of intensive neurorehabilitation combined with mesenchymal stem cell transplantation (INSCP) in dogs with degenerative myelopathy (DM). The study found that the INSCP...
KEY FINDING: The INSCP group (intensive neurorehabilitation with stem cells) had a mean survival time of 438 days, compared to 274 days for the ARP group (ambulatory rehabilitation protocol).
BMC Veterinary Research, 2023 • September 27, 2023
This study successfully isolated, propagated, and differentiated canine NSPCs derived from the cervical spinal cord in adult canines, demonstrating their potential for spinal cord regeneration. The is...
KEY FINDING: Canine cervical spinal cord-derived NSPCs can be isolated and propagated for at least 10 passages.
Veterinary and Animal Science, 2023 • October 30, 2023
This case report investigated the therapeutic potential of amniotic fluid-derived mesenchymal stem cells (AF-MSCs) in dogs with spinal cord injuries. A 2-year-old male beagle dog with an injury in the...
KEY FINDING: AF-MSC transplantation improved hind limb movement in a dog with a lumbar spinal cord injury.
Regenerative Therapy, 2023 • October 26, 2023
This study investigates the potential of autologous bone marrow-derived mononuclear cell (BM-MNC) transplantation into cerebrospinal fluid for treating acute spinal cord injury (SCI) in a canine model...
KEY FINDING: MRI revealed that the signal intensity reduced over time in both BM-MNCetreated and control groups.
International Journal of Surgery, 2024 • January 24, 2024
Mesenchymal stem cell therapy holds significant promise for treating SCI, aiming to restore motor and sensory function. Transplanted MSCs play a crucial role in SCI treatment. They not only provide neu...
KEY FINDING: MSCs can differentiate into multiple cell lineages including osteoblasts, chondrocytes, adipocytes, fibroblasts, neurons and glial cells, making them appealing for therapeutic applications.
BMC Veterinary Research, 2024 • February 8, 2024
This study compared the therapeutic effects of stem cells and stem cell-derived exosomes in treating induced multiple sclerosis (MS) in dogs. Both treatments were administered intrathecally, and their...
KEY FINDING: Both stem cell and exosome treatments improved clinical signs in dogs with induced MS compared to the control group. Magnetic resonance imaging (MRI) showed a resolution of hyperintense lesions in the treated groups by the end of the study.