Neural stem/progenitor cells from adult canine cervical spinal cord have the potential to differentiate into neural lineage cells

This study focuses on isolating and culturing neural stem/progenitor cells (NSPCs) from the cervical spinal cord of adult dogs because dogs share similar diseases and environments with humans, making them a good model for studying human conditions. The researchers were able to isolate and grow these cells for up to 10 passages, maintaining their ability to multiply without changes in proliferation rate. The cells could form neurospheres and also differentiate into neural lineage cells like astrocytes, neurons, and oligodendrocytes. This research provides a foundation for using canine NSPCs in spinal cord regeneration studies, potentially benefiting both veterinary and human medicine by offering a new approach to treating spinal cord injuries.

• 1
  Canine cervical spinal cord-derived NSPCs can be isolated and propagated for at least 10 passages.
• 2
  These NSPCs retain the capacity to differentiate into neuronal and glial cells.
• 3
  Specific medium compositions can promote differentiation of NSPCs into desired cell types.