Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 7,771-7,780 of 7,812 results
Neuroscientist, 2010 • April 1, 2010
MMPs are implicated in both injury and recovery processes following CNS trauma. Early MMP activity is generally detrimental, promoting barrier dysfunction and inflammation, while later MMP activity mo...
KEY FINDING: MMP-9 is elevated early after injury and is associated with blood-brain barrier disruption and inflammation, while MMP-2 is upregulated later and involved in wound healing.
The Journal of Neuroscience, 2010 • April 28, 2010
This study investigates the role of keratan sulfate (KS) in functional recovery after spinal cord injury (SCI) using N-acetylglucosamine 6-O-sulfotransferase-1 (GlcNAc6ST-1)-deficient mice, which lack...
KEY FINDING: Mice lacking N-acetylglucosamine 6-O-sulfotransferase-1 (GlcNAc6ST-1), and thus deficient in keratan sulfate, exhibit significantly better motor function recovery after spinal cord injury, as measured by footfall tests, footprint tests, and Basso mouse scale locomotor scoring.
J Clin Immunol, 2010 • May 1, 2010
Spinal cord injury (SCI) involves a primary mechanical trauma followed by a secondary injury cascade, including neuroinflammation, that exacerbates the initial damage. Neuroinflammation, while importa...
KEY FINDING: IgG can modulate the immune response by inducing apoptosis in leukocytes, neutralizing components of the complement system, and inhibiting the activation of leukocytes.
Exp Neurol, 2010 • August 1, 2010
The study investigated the effects of peripheral nerve grafts (PNG) and acidic fibroblast growth factor (αFGF) combined with step training on locomotor performance in rats with complete spinal cord tr...
KEY FINDING: PNG plus αFGF treatment resulted in a clear improvement in locomotor performance with or without step training.
J. Comp. Neurol., 2010 • March 23, 2010
This study used lampreys to investigate the regeneration of synapses after spinal cord injury, focusing on the giant reticulospinal (RS) neurons. The key finding was that despite robust functional rec...
KEY FINDING: Regenerated giant RS axons produced very few synapses compared to control axons, particularly within and distal to the lesion scar.
Cold Spring Harb Perspect Biol, 2010 • January 1, 2010
Injury to the adult spinal cord causes substantial damage and often leads to permanent functional deficits. Research aims to re-establish neuronal connectivity lost after injury, which may involve sho...
KEY FINDING: Axon guidance molecules, initially important for neural development, are also present in the mature CNS, influencing network refinement, neuronal excitability, and synaptic function.
BMC Neuroscience, 2010 • June 4, 2010
The study examines the intrinsic post-axotomy response of thoracic propriospinal (TPS) neurons following spinal cord injury (SCI), focusing on changes in gene expression at different time points. The ...
KEY FINDING: A strong and early upregulation occurs in the expression of genes involved in the immune/inflammatory response that returned towards normal by 1-week post-injury.
PNAS, 2010 • June 22, 2010
The study examines the topographic specificity of sensory axon regeneration in the spinal cord following dorsal root crush, using soluble Nogo receptor peptide (sNgR) and artemin (ART) treatments. sNg...
KEY FINDING: Artemin (ART) treatment promotes topographically specific regeneration of sensory axons after dorsal root crush, while soluble Nogo receptor peptide (sNgR) does not.
Neuron, 2010 • June 10, 2010
The study investigates the role of myelin inhibitors Nogo, MAG, and OMgp in axon regeneration and sprouting after spinal cord injury using genetically modified mice. Results indicate that deleting any...
KEY FINDING: Deleting any one of the inhibitors (Nogo, MAG, or OMgp) enhanced sprouting of corticospinal or raphespinal serotonergic axons.
Nat Rev Neurol, 2010 • July 1, 2010
Stem cell therapy holds promise for treating spinal cord injury (SCI) by potentially replacing damaged cells, providing trophic support, and facilitating axon regeneration. While stem cell transplanta...
KEY FINDING: Stem cell transplantation strategies for SCI include replacing lost or damaged cells (neurons and oligodendrocytes), providing trophic support, and manipulating the environment to facilitate axon regeneration.