Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 7,761-7,770 of 7,812 results
JoVE, 2009 • January 1, 2009
One of the goals of our research is to promote axon regeneration to restore connectivity across the lesion site. Importantly, the peripheral nerve grafting approach is effective in promoting regenerat...
KEY FINDING: Ascending and descending spinal axons will enter the graft, grow in a relatively straight line parallel to the length of the graft and extend to the distal end of the graft at a rate of approximately 1 mm per day.
The Journal of Neuroscience, 2009 • November 25, 2009
This study demonstrates that administering ChABC to a distal graft interface allows for functional axonal regeneration by chronically injured neurons. The researchers combined grafting of a peripheral...
KEY FINDING: ChABC treatment digests CSPGs within a chronic scar, which promotes behavioral recovery after chronic SCI.
The Journal of Neuroscience, 2009 • November 25, 2009
This study evaluated the therapeutic potential of human mesenchymal stem cells (hMSCs) and brain-derived neurotrophic factor-secreting hMSCs (BDNF-hMSCs) in a rat model of spinal cord injury (SCI). Th...
KEY FINDING: Transplantation of BDNF-hMSCs resulted in improved locomotor recovery compared to hMSC transplantation alone.
The Journal of Neuroscience, 2009 • December 2, 2009
This study demonstrates that adult zebrafish possess a subpopulation of ependymoradial glial cells that retain transcription factor expression of the embryonic pMN zone. It provides evidence that thes...
KEY FINDING: Adult zebrafish spinal cord contains ependymoradial glial cells that retain transcription factor expression of the embryonic pMN zone.
PLoS ONE, 2009 • December 3, 2009
This study investigates the mechanism by which olfactory ensheathing cells (OECs) migrate to the glial scar after spinal cord injury (SCI) in rats. The research found that reactive astrocytes in the g...
KEY FINDING: Glial scar tissue and reactive astrocyte-conditioned medium promote OECs migration in vitro.
Exp Neurol, 2010 • March 1, 2010
This study examined the origin and distribution of noradrenergic (NA) axons in the spinal cord caudal to a complete transection in adult rats, focusing on the impact of olfactory ensheathing glia (OEG...
KEY FINDING: NA axons are present throughout the caudal stump of both media- and OEG-injected spinal rats, entering the spinal cord from the periphery via dorsal and ventral roots and along large penetrating blood vessels.
Brain, 2010 • January 19, 2010
This study characterizes a novel cell preparation method that assesses, quickly and effectively, the changes in the principal immune cell types by flow cytometry in the injured spinal cord, daily for t...
KEY FINDING: The study quantitatively demonstrates a novel time-dependent multiphasic response of cellular inflammation in the spinal cord after spinal cord injury.
Exp Neurol, 2010 • June 1, 2010
This study investigates the role of EphA4 in astroglial-fibrotic scar formation after spinal cord injury (SCI) using EphA4 mutant mice. The results indicate that EphA4 deletion does not significantly ...
KEY FINDING: EphA4 expression is primarily associated with astrocytes in the spinal cord and neurons in the cerebral cortex before and after SCI.
BMC Neuroscience, 2010 • February 18, 2010
The study aimed to use RNAi to knock down Semaphorin receptors Npn-1 and Npn-2 in spinal nerve tracts to promote axon regeneration after spinal cord injury. Effective shRNAs were developed to knock do...
KEY FINDING: shRNAs can effectively knock down Npn-1 and Npn-2 expression in neuronal cell lines in vitro using lentiviral delivery.
JOURNAL OF NEUROTRAUMA, 2014 • September 15, 2014
This study demonstrates that FGF-2 administration into the spinal cord dramatically enhanced locomotor functional recovery after complete transection of the spinal cord in rats. The FGF-2-enhanced rec...
KEY FINDING: FGF-2 injection markedly improved locomotor function in rats after complete spinal cord transection.