Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 21-30 of 7,812 results
Neuroscience, 2011 • July 14, 2011
This study investigates the role of microRNAs (miRNAs) in spinal cord injury (SCI) by comparing miRNA expression in contused and sham rat spinal cords at 4 and 14 days post-injury. The researchers ide...
KEY FINDING: Several miRNAs, including miR124, miR129, and miR1, were significantly down-regulated following spinal cord contusion, while miR21 was significantly induced.
PNAS, 2011 • May 10, 2011
The study demonstrates that Smad1-dependent BMP signaling is developmentally regulated and governs axonal growth potential in DRG neurons. Reactivation of Smad1 in adult DRG neurons, achieved through ...
KEY FINDING: Smad1-dependent BMP signaling is developmentally regulated and governs axonal growth in dorsal root ganglion (DRG) neurons.
Gene Ther., 2012 • January 1, 2012
This study systematically compared seven AAV serotypes and an integration-deficient lentiviral vector for their ability to transduce corticospinal neurons (CSNs) following intracortical injection in r...
KEY FINDING: AAV1 was the most effective serotype for transducing cortical and CSNs, with GFP expression detectable in fibers projecting through the dorsal corticospinal tract (dCST) of the cervical spinal cord.
Stem Cells and Cloning: Advances and Applications, 2012 • September 24, 2012
Stem cell transplantation offers potential for restoring function and easing the burden associated with spinal cord injury (SCI). The most convincing results have been obtained with neural progenitor ...
KEY FINDING: Neural progenitor cells have yielded the most promising outcomes in preclinical models of SCI treatment.
Exp Neurol, 2012 • May 1, 2012
Myelin-associated inhibitors of axon growth, including Nogo, MAG and OMgp, have been the subject of intense research to promote axonal repair after spinal cord injury. Different definitions of axon sp...
KEY FINDING: Genetic analysis using Nogo knockout mice produced different outcomes ranging from robust, suggestive, to no regeneration, which have led to a major controversy regarding Nogo’s role in axon regeneration.
J Neurosci Methods, 2011 • August 15, 2011
This study demonstrates the efficacy of a lentiviral vector (Chase/LV) encoding chondroitinase AC (Chase) in vitro and in vivo to degrade CSPGs. Chase/LV-infected cells showed sustained expression of ...
KEY FINDING: Neural precursor cells infected with Chase/LV expressed the GFP reporter, and the expression increased over time in culture, indicating successful transduction and expression of the transgene.
Cell Mol Neurobiol, 2011 • May 21, 2011
This study investigates the expression and role of ephrinA ligands, particularly ephrinA1, after spinal cord injury (SCI) in adult rats. The researchers found that ephrinA1 mRNA levels were significan...
KEY FINDING: EphrinA1 was the only ligand whose mRNA levels were significantly altered after SCI.
PLoS ONE, 2011 • May 18, 2011
This study evaluated the neurorigenerative properties of RADA16-4G-BMHP1 SAP by injecting the scaffold immediately after contusion in the rat spinal cord, then evaluating the early effects by semi-qua...
KEY FINDING: The functionalized SAP, RADA16-4G-BMHP1, induced a general upregulation of GAP-43, trophic factors and ECM remodelling proteins at 7 days after lesion.
Cell Mol Neurobiol, 2011 • June 1, 2011
This study investigates the effect of ChABC on axon regeneration after spinal cord injury in rats. The researchers found that ChABC treatment decreased NG2 expression and enhanced GAP-43 expression at...
KEY FINDING: Multiple injections of ChABC decreased NG2 expression at the lesion site at 5 and 7 days after injury compared to vehicle-treated rats.
J Biomed Mater Res A, 2011 • September 1, 2011
The study investigates the use of PLG bridges to deliver VEGF and FGF-2 to promote angiogenesis and nerve growth after spinal cord injury. The method of protein incorporation affects release, with enc...
KEY FINDING: Encapsulation of proteins within microspheres resulted in slower protein release compared to mixing proteins directly into the bridge material.