Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 221-230 of 7,812 results
JOURNAL OF NEUROTRAUMA, 2014 • August 1, 2014
The MIASCI draft standard has been proposed to capture SCI experimental details, including the investigator, organism, behavior, surgery, perturbagens, histology, immunohistochemistry, imaging, biomat...
KEY FINDING: Transparent reporting standards for experiments using animal models of human SCI aim to reduce inherent bias and increase experimental value.
The Journal of Neuroscience, 2014 • May 28, 2014
This study investigates the role of astrocyte GLT1 overexpression in a rat model of cervical spinal cord injury (SCI). The results showed that astrocyte-targeted GLT1 overexpression increased lesion s...
KEY FINDING: GLT1 expression in astrocytes decreases following cervical spinal cord injury in mice, persisting for at least 6 weeks.
Exp Neurol, 2014 • November 1, 2014
This study investigated the long-term survival, axonal growth-promotion, and myelination potential of Schwann cells (SCs) grafted into a contused spinal cord in adult rats. The key findings revealed r...
KEY FINDING: Grafted SCs-GFP exhibited remarkable survival up to 24 weeks post-grafting in the contused spinal cord of adult rats.
BMC Neuroscience, 2014 • May 5, 2014
This study investigates the potential of boundary cap neural crest stem cells (bNCSCs) to aid sensory axon regeneration after dorsal root avulsion injury in adult rodents. bNCSCs were implanted into t...
KEY FINDING: Transplanted bNCSCs showed extensive survival and differentiation after transplantation to the avulsed DRTZ.
Front Biol (Beijing), 2014 • February 1, 2014
This review examines the role of surgical decompression in treating acute spinal cord injury (SCI), considering both clinical and animal studies. The timing of surgery is a key factor, with evidence s...
KEY FINDING: Early surgical decompression (within 24 hours of injury) may lead to better neurological outcomes, reduced complications, and shorter hospital stays compared to delayed surgery.
PLoS ONE, 2014 • June 10, 2014
This study analyzes the transcriptome and proteome of Monodelphis domestica after spinal cord injury at two postnatal ages, P7 and P28. At P7, only 40 genes changed expression, mostly related to immun...
KEY FINDING: Following injury at P7 only forty genes changed (all increased expression); most were immune/inflammatory genes.
JOURNAL OF NEUROTRAUMA, 2014 • November 1, 2014
This study investigates the effects of a TLR9 antagonist on bladder function and tissue sparing in mice with spinal cord injury (SCI). The results showed that the TLR9 antagonist decreased urinary ret...
KEY FINDING: The TLR9 antagonist (CpG ODN 2088) decreased urinary retention in mice with SCI.
Exp Neurol, 2014 • November 1, 2014
This study replicated some, but not all, of the previously reported benefits of Taxol in rat models of spinal cord injury. Taxol was found to reduce fibrotic scarring in both dorsal hemisection (DHx) ...
KEY FINDING: Taxol significantly reduced scarring at the injury site after dorsal spinal hemisection (DHx).
Neural Regen Res, 2014 • February 1, 2014
Glial cells in the central nervous system (CNS) contribute to formation of the extracellular matrix, which provides adhesive sites, signaling molecules, and a diffusion barrier to enhance efficient ne...
KEY FINDING: Following CNS injury, glial cells activate and alter the ECM composition at the lesion border, creating a growth-inhibitory environment.
PLoS ONE, 2014 • July 8, 2014
The study aimed to assess the impact of absent corticospinal input on recovery from brachial plexus injury (BPI) using a mouse model with congenital absence of the corticospinal tract (CST). Results i...
KEY FINDING: Mice lacking the corticospinal tract (CST) showed impaired recovery of elbow flexion after brachial plexus injury and root re-implantation, as measured by grooming tests and Catwalk analysis.