Research Methodology & Design Research

KEY FINDING: There is ambiguous classification of intervention type across trials, hindering understanding of available trials.

KEY FINDING: NHP models replicate human SCI symptoms better than rodent models due to closer phylogenetic association and neuroanatomical similarities.

KEY FINDING: The guidelines strongly recommend surgical decompression within 24 hours of injury when medically feasible, based on evidence showing improved outcomes with early surgery.

KEY FINDING: Updated guidelines were established for the timing of surgical decompression after acute SCI, with surgical decompression within 24 hours of injury now “recommended” as a treatment option.

KEY FINDING: The patient presented with a complete C4-C5 dislocation, C4 spondyloptosis, severe kyphotic angulation, spinal cord compression, and severe myelopathy.

KEY FINDING: The patient presented with cauda equina syndrome symptoms including difficulty walking, urinary dribbling, reduced perianal sensation, and absent voluntary anal contraction.

KEY FINDING: Female gender, neurologic conditions, and long-term catheterization were identified as predominant risk factors for ureteral cannulation.

KEY FINDING: This process resulted in both systematic reviews and clinical practice guidelines/care pathways related to the role and timing of surgery in acute SCI; the optimal hemodynamic management of acute SCI; and the prevention, diagnosis and management of ISCI.

KEY FINDING: BHD combination therapy significantly improved the patient-perceived total clinical effective rate (TER) compared to the control group.

KEY FINDING: Emergency closed reduction with cranial tong traction can successfully reduce bilateral facet joint dislocations and odontoid fractures.