Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 71-80 of 2,298 results
Journal of Brachial Plexus and Peripheral Nerve Injury, 2012 • April 30, 2012
The present study indicates a discrepancy between functional recovery evaluated by toe spreading and structural regeneration analyzed by retrograde tracing. Toe spreading of ANT animals improved signi...
KEY FINDING: ANT animals did not reach pre-surgical levels of toe spreading at the end of the observation period.
Mol Cell Neurosci, 2012 • June 1, 2012
This study investigates the role of PlexinA2 in limiting axonal growth and recovery after CNS injury. It finds that PlexinA2, a receptor for oligodendrocyte-derived Sema6A, restricts axon growth in th...
KEY FINDING: Outgrowth from adult PlexinA2-/- neurons is not inhibited by Sema6A in vitro.
Journal of Neuroinflammation, 2012 • May 7, 2012
This study investigates the role of IFNγ in synaptic plasticity and nerve regeneration following peripheral nerve injury in mice. The researchers compared wild-type mice with IFNγ−/− mutant mice after...
KEY FINDING: IFNγ−/− mutant mice showed decreased expression of MHC I and β2-microglobulin mRNA in the lesioned spinal cord segment.
Cell Mol Neurobiol, 2012 • May 10, 2012
This study investigates the mechanism by which neural stem cell (NSC) transplantation improves functional outcomes after spinal cord injury (SCI) in rats. The study found that NSC transplantation impr...
KEY FINDING: Transplantation of NSCs significantly improved hindlimb locomotor functions in adult rats subjected to transection of the spinal cord.
The Journal of Neuroscience, 2012 • May 23, 2012
The study investigates the roles of kindlin-1 and kindlin-2 in axon growth and regeneration, focusing on integrin activation and signaling. Kindlin-1 overexpression enhances integrin activation, promo...
KEY FINDING: Kindlin-2 is present in the nervous system, whereas Kindlin-1 is not naturally expressed.
J Control Release, 2012 • August 10, 2012
This study introduces drug-eluting microfibrous patches as a platform for the local delivery of rolipram to treat spinal cord injuries in rats. The patches were designed to control the release of roli...
KEY FINDING: Low-dose rolipram patches led to significant improvements in functional outcomes, with higher Martinez forelimb open-field scores compared to all other groups.
The Journal of Neuroscience, 2012 • May 30, 2012
This study investigates the role of Fgf signaling in spinal cord regeneration in zebrafish, focusing on glial cell behavior. Unlike mammals, zebrafish glia form a bridge across the injury site, which ...
KEY FINDING: Following spinal cord injury in zebrafish, glial cells proliferate, migrate, and differentiate to form a glial cell bridge, which is crucial for axonal regeneration.
JOURNAL OF NEUROTRAUMA, 2012 • August 10, 2012
The study evaluated the efficacy of dissociated predegenerated nerve (dPDN) transplants in promoting spinal cord regeneration and functional recovery in rats with spinal cord injuries, comparing them ...
KEY FINDING: dPDN grafts survive within the injured spinal cord and promote the ingrowth of axons to a similar extent as purified Schwann cell (SC) grafts.
BMC Neuroscience, 2012 • June 6, 2012
The study aimed to assess the impact of vascular endothelial growth factor (VEGF) gene therapy on musculocutaneous nerve (MCN) reinnervation following end-to-end (ETE) or end-to-side (ETS) neurorrhaph...
KEY FINDING: Plasmid phVEGF transfection increased VEGF protein levels in Schwann cells of the MCN stumps.
PLoS ONE, 2012 • May 31, 2012
The study examines cellular mechanisms underlying repetitive regeneration of myogenic tissues in the electric fish S. macrurus. In vivo microinjection studies revealed no fragmentation or cellularizat...
KEY FINDING: Pax7-positive muscle stem cells are found in both muscle fibers and electrocytes, the non-contractile cells of the electric organ.