Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 81-90 of 2,298 results
The Journal of Neuroscience, 2012 • June 13, 2012
This study investigated the efficacy of combinatorial treatments in promoting motor axonal regeneration after partial and complete spinal cord transections in rats. The treatments included cAMP inject...
KEY FINDING: Combinatorial treatment with cAMP injections, bone marrow stromal cell grafts, and BDNF gradients resulted in motor axon regeneration beyond both C5 hemisection and T3 complete transection sites in rats.
PLoS ONE, 2012 • June 6, 2012
The study aimed to identify PNS genes that could enhance the regenerative ability of CNS neurons by promoting neurite growth on inhibitory substrates. A high-content screen of over 1100 PNS genes in c...
KEY FINDING: Several known growth associated proteins potentiated neurite growth on laminin.
PLoS ONE, 2012 • June 20, 2012
This study demonstrates that intravenous administration of MSCs improves functional recovery in rats after spinal cord injury. The beneficial effects of MSCs are likely mediated by paracrine mechanism...
KEY FINDING: Intravenously grafted MSCs induced an early improvement in open field and grid navigation scores in rats with spinal cord injuries.
Exp Neurol, 2012 • September 1, 2012
This study investigates the use of a herpes simplex virus (HSV) vector to deliver the C3 transferase (C3t) gene into dorsal root ganglion (DRG) neurons to promote axonal regeneration after cervical ro...
KEY FINDING: HSV vector vC3t produces C3 transferase (C3t) in vitro and in vivo, inhibiting Rho GTPase activity in DRG neurons.
Molecular Neurodegeneration, 2012 • July 13, 2012
This study investigates the role of bone marrow-derived cells (BMMCs) and fibroblast growth factor-2 (FGF-2) in promoting glial cell proliferation during peripheral nerve regeneration after sciatic ne...
KEY FINDING: Bone marrow-derived cell treatment induces an increase in the expression of FGF-2 in the sciatic nerve, dorsal root ganglia and the dorsolateral (DL) region of the lumbar spinal cord (LSC) in a model of sciatic nerve transection.
J. Cell. Mol. Med., 2012 • November 1, 2012
This review highlights promising clinical approaches to promote spinal cord regeneration, including those in clinical trials, but notes that axonal re-growth is modest, even with cleared inhibitory cu...
KEY FINDING: Cell-based therapy for SCI can replace lost cellular elements, including neurons and oligodendrocytes, which form myelin sheaths around axons.
PNAS, 2012 • July 24, 2012
This study examines the regeneration of the central and peripheral nervous systems during axolotl tail regeneration, focusing on the origin of dorsal root ganglia (DRG), Schwann cells, and melanophore...
KEY FINDING: The correct number and spacing of dorsal root ganglia (DRG) are regenerated after tail amputation in axolotls.
Exp Neurol, 2012 • October 1, 2012
This review focuses on CSPG-mediated inhibition and CSPG receptors identified recently, as severed axons in adult mammals do not regenerate appreciably after central nervous system (CNS) injury due to...
KEY FINDING: Two members of the LAR phosphatase subfamily, PTPσ and LAR, are functional receptors that bind CSPGs with high affinity and mediate CSPG inhibitory effects.
PNAS, 2012 • September 4, 2012
This study investigates the role of Wnt signaling in limiting the regenerative potential of sensory axons in the spinal cord following a conditioning lesion. The research demonstrates that blocking Wn...
KEY FINDING: Peripheral conditioning injury induces the expression of the repulsive Wnt receptor Ryk in sensory neurons.
Cell Cycle, 2012 • September 15, 2012
The study demonstrates that multipotent, nestin-expressing stem cells are present throughout the hair follicle and that the upper part of the follicle can produce the stem cells in large amounts that ...
KEY FINDING: Nestin-expressing cells are located in all regions of the hair follicle (upper, middle, and lower parts of the vibrissa follicle).