Browse the latest research summaries in the field of physiology for spinal cord injury patients and caregivers.
Showing 231-240 of 321 results
Eur Spine J, 2011 • January 9, 2011
This study quantified the Trömner sign using electrophysiological assessments to evaluate its diagnostic sensitivity for cervical spondylotic myelopathy (CSM). The results demonstrated that the quant...
KEY FINDING: Quantified electrophysiological tests showed positive Tro¨mner signs in all CSM patients, indicating high sensitivity.
BMC Neuroscience, 2013 • August 2, 2013
This study investigates the early molecular adaptations in rat soleus muscle after initiating isometric resistance exercise by electrical stimulation (ES) following spinal cord injury (SCI). ES increa...
KEY FINDING: ES increased expression of Hey1 and Pitx2, suggesting increased Notch and Wnt signaling, respectively, indicating involvement of these pathways in ES-induced muscle mass increases.
JOURNAL OF NEUROTRAUMA, 2012 • March 20, 2012
This study characterizes clonus in individuals with chronic cervical spinal cord injuries, focusing on muscle activation patterns and factors influencing clonus duration. Electromyographic activity wa...
KEY FINDING: Clonus frequency in the soleus muscle averaged 5.4 Hz and was slower when the reflex path was longer, indicating afferent input influences clonus.
Clin Neurophysiol, 2012 • March 1, 2012
This study demonstrated that mechanical oscillation of a single paralyzed limb segment modulates the amplitude of the H-reflex and influences the degree of post-activation depression in healthy and th...
KEY FINDING: Segmental vibration resulted in H-reflex depression in both SCI and healthy control groups.
Nat Mater., 2011 • December 1, 2011
The study demonstrates a novel electrochemical method for modulating nerve activity by using ion-selective membranes (ISMs) to control ion concentrations in situ. The use of ISMs allows for both the r...
KEY FINDING: Calcium ion depletion using ISMs can reduce the electrical threshold for nerve stimulation by approximately 40%.
Frontiers in Neurology, 2017 • June 20, 2017
We have demonstrated that, in SCI, multifrequency EIM patterns differ substantially from those in healthy control subjects at biceps brachii, especially the reactance and phase angle. Our results reve...
KEY FINDING: The results showed that there was a significant decrease in muscle reactance (X) and phase angle (θ) at selected frequencies (i.e., 50 and 100 kHz) in SCI compared to control.
Biochemistry and Biophysics Reports, 2017 • January 17, 2017
This study investigates the effects of myostatin and an ALK4/5/7 inhibitor (SB431542) on miRNA expression in differentiating C2C12 myoblasts to understand the regulation of muscle-specific and highly ...
KEY FINDING: Myostatin (1 µg/ml) reduced the expression of miR-1 and miR-133a at 1 day post-differentiation induction but not at 3 days.
Frontiers in Physiology, 2017 • July 18, 2017
The study investigated the use of heart rate variability (HRV) to diagnose neuropathic pain (NP) in individuals with spinal cord injury (SCI). The results indicated that participants with SCI and NP e...
KEY FINDING: SCI+NP participants demonstrated lower overall HRV, as determined by the SDNN time domain parameter, compared to either AB (p < 0.01) or SCI-NP (p < 0.05) groups.
The Journal of Spinal Cord Medicine, 2018 • January 1, 2018
This mini-review presents evidence for TRT as a potential strategy to aid in the management of body composition changes and to improve metabolism in persons with SCI. In the absence of adequate studie...
KEY FINDING: Transdermal TRT can increase LBM and reduce FM over 3–36 months, relative to placebo, in hypogonadal elderly men and to a lesser extent in men with SCI.
Arch Phys Med Rehabil, 2018 • March 1, 2018
This study evaluated the effects of pressure threshold respiratory training (RT) on heart rate variability and baroreflex sensitivity in persons with chronic spinal cord injury (SCI). The results indi...
KEY FINDING: Respiratory training significantly increased FVC and FEV1 in the RT group compared to controls.