Browse the latest research summaries in the field of physiology for spinal cord injury patients and caregivers.
Showing 111-120 of 321 results
Journal of Cachexia, Sarcopenia and Muscle, 2022 • January 9, 2022
This study demonstrates that Numb protein levels decline with age in skeletal muscle. The loss of Numb in skeletal muscle fibers leads to reduced contractile function, altered sarcomere length, and de...
KEY FINDING: Numb protein expression decreases significantly with age in mouse skeletal muscle.
Molecular Pain, 2022 • January 1, 2022
The study evaluated the effect of differential target multiplexed programming (DTMP) spinal cord stimulation (SCS) on proteins involved in ion transport regulation in the spinal cord of rats with neur...
KEY FINDING: DTMP modulated a larger number of proteins involved in ion transport regulation compared to LR SCS.
PLoS ONE, 2022 • January 24, 2022
This study investigated the effects of FESRT on body composition in individuals within 24 months of SCI. The results indicated that FESRT significantly increased exercise capacity, lean mass, and atte...
KEY FINDING: FESRT resulted in a significant increase in total and leg lean mass compared to standard of care.
Spinal Cord Series and Cases, 2022 • February 1, 2022
This study aimed to determine the feasibility and relevance of assessing corticospinal, sensory, and spinal pathways early after traumatic SCI in a rehabilitation setting. The study validated whether ...
KEY FINDING: Electrical perceptual threshold (EPT) measured at IFR correlated with LEMS in the chronic phases (r = −0.67).
Frontiers in Physiology, 2022 • February 10, 2022
This study investigated the relationship between visceral adiposity, inflammation, testosterone, and mitochondrial health in individuals with chronic spinal cord injury (SCI). The study found that incr...
KEY FINDING: Citrate synthase (CS) activity, a measure of mitochondrial mass, was negatively associated with visceral adipose tissue (VAT) and C-reactive protein (CRP), an inflammatory marker.
Nature Communications, 2022 • March 15, 2022
This study investigates the impact of spinal cord injury (SCI) on cardiac function, focusing on the role of bulbospinal sympathetic control. Using rat models and clinical studies, the research demonst...
KEY FINDING: High-level SCI leads to a rapid and sustained reduction in left ventricular contractile function, preceding structural changes in the heart.
Int. J. Environ. Res. Public Health, 2022 • April 13, 2022
The study evaluated muscle strength in the upper extremities of SCI patients compared to a control group, finding significant weakness in most muscles. Muscle strength rankings differed between SCI an...
KEY FINDING: The majority of the upper extremity muscles (12 out of 15) showed considerable weakness (24 to 53%) relative to the control group.
Spinal Cord Series and Cases, 2022 • April 14, 2022
This study compared locomotor-respiratory coupling (LRC) in ambulatory adults with incomplete spinal cord injury (iSCI) to able-bodied controls during over ground and treadmill walking. The results in...
KEY FINDING: Participants with iSCI demonstrated significantly more LRC than able-bodied controls during over ground walking.
Br J Nutr, 2023 • December 24, 2023
This study investigated the relationship between macronutrient intakes and body composition in individuals with chronic SCI using the Geometric Framework for Nutrition (GFN). The study found that carb...
KEY FINDING: Carbohydrates were negatively associated with several measures of fat mass as measured by DXA.
J. Pers. Med., 2022 • July 11, 2022
The pathophysiology of SCI involves structural disruption, primary traumatic injury, and secondary injury mechanisms, leading to cell death, inflammation, and long-term complications. Clinical classif...
KEY FINDING: Acute SCI pathophysiology involves primary instantaneous injury and secondary progressive injury processes, where secondary damage can be attenuated.