Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 341-350 of 639 results
J Pain, 2016 • September 1, 2016
This study investigated the analgesic efficacy of vaporized cannabis in patients with neuropathic pain related to spinal cord injury or disease. Participants underwent a randomized, double-blind, plac...
KEY FINDING: Vaporized cannabis provided significant pain relief compared to placebo in participants with neuropathic pain related to spinal cord injury or disease.
Osteoporos Int, 2016 • December 1, 2016
This study prospectively assessed factors associated with change in bone density over a mean of 21 months in 152 men and women with chronic SCI. We found no association between bone loss and tradition...
KEY FINDING: Wheelchair users experienced bone loss compared to those who could walk.
BMJ Open, 2016 • June 1, 2016
The SCISSOR study is a clinical trial protocol investigating the use of high-dose ibuprofen to promote recovery after acute traumatic spinal cord injury (SCI). Ibuprofen acts as a 'small-molecule' Rho...
KEY FINDING: Preclinical evidence suggests that ibuprofen, through Rho inhibition, may enhance motor recovery after SCI. Meta-analysis supported this, showing a 20.2% improvement in motor outcome with ibuprofen/indometacin treatment compared to controls.
Medicine, 2014 • December 1, 2014
This study analyzed a large claims database to compare the effectiveness of different oral antibiotics for urinary tract infections (UTIs) in outpatients. The results suggest that norfloxacin and oflo...
KEY FINDING: Norfloxacin had the lowest treatment failure rate compared to TMP-SMX in crude estimate (OR, 0.73; 95% CI, 0.57–0.94), individual covariate adjustment (OR, 0.70; 95% CI, 0.54–0.90), and propensity score matched analysis (OR, 0.73; 95% CI, 0.54–1.00).
Clinical Neuropharmacology, 2016 • November 1, 2016
Traumatic brain injury (TBI) is an alteration in brain function, caused by an external force...Traumatic brain injury is a major cause of morbidity and mortality worldwide. Baclofen is a muscle relaxa...
KEY FINDING: Spasticity in TBI is estimated to be between 17% and 50% of patients with moderate to severe TBI that presents increased muscle tone or spasticity.
Journal of Pain Research, 2016 • August 31, 2016
This study evaluated the relationship between plasma concentrations of cannabinoids and the analgesic response to vaporized cannabis in 42 subjects with central neuropathic pain. The study found dose-...
KEY FINDING: Dose-dependent improvement in pain score was evident across all pain scale elements after administration of vaporized cannabis.
Neural Regeneration Research, 2014 • December 1, 2014
Previous experimental studies have shown that cerebral infarction can be effectively reduced following treatment with scutellaria baicalensis stem-leaf total flavonoid (SSTF). Experimental findings in...
KEY FINDING: Pretreatment with SSTF effectively improved neurological function, reduced brain water content and the permeability of blood vessels.
Korean J Physiol Pharmacol, 2015 • March 1, 2015
This study investigated the synergistic effects of combining morphine and CI-988, a cholecystokinin type B antagonist, on neuropathic pain in rats after spinal cord injury. The results showed that int...
KEY FINDING: Both morphine and CI-988, when given individually, increased the pain threshold in rats with spinal cord injuries.
Journal of Visualized Experiments, 2016 • September 12, 2016
The study presents a protocol to differentiate between immune system suppression and CNS protection for pharmacological interventions in autoimmune demyelination. It utilizes EAE models in mice, combi...
KEY FINDING: The protocol differentiates between treatments that suppress the immune system and those that directly protect the CNS during autoimmune demyelination.
The Journal of Spinal Cord Medicine, 2018 • January 1, 2018
This study evaluated the bronchodilator effects of ipratropium bromide (IB) and albuterol sulfate (AS) in subjects with tetraplegia using spirometry, body plethysmography, and impulse oscillation syst...
KEY FINDING: Both ipratropium bromide (IB) and albuterol sulfate (AS) elicit significant bronchodilation in subjects with tetraplegia, as demonstrated by improvements in spirometry and specific airway conductance.