Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 411-420 of 682 results
Stem Cell Research & Therapy, 2021 • January 31, 2021
This study demonstrates that NCSCs delivered at the injury site using a scaffold ameliorate neuropathic pain and enhance locomotion after PNI through inhibiting glial activation as well as ERK and NF-...
KEY FINDING: NCSC-laden nerve scaffolds mitigated SNT-induced neuropathic pain and improved motor function recovery after sciatic nerve repair.
Dtsch Arztebl Int, 2022 • December 2, 2022
Complex regional pain syndrome (CRPS) is a relatively common complication, occurring in 5% of cases after injury or surgery, particularly in the limbs. The incidence of CPRS is around 5–26/100 000. Re...
KEY FINDING: CRPS is now categorized as a primary pain condition of multifactorial origin under the ICD-11.
Top Spinal Cord Inj Rehabil, 2021 • January 1, 2021
A traumatic injury to the spinal cord causes an immediate cascade of inflammatory responses that, among other things, can initiate hypersensitivity within nociceptive pathways leading to chronic neuro...
KEY FINDING: Higher BMI is associated with greater pain severity in persons with chronic SCI, irrespective of the type of pain.
Molecular Pain, 2021 • March 9, 2021
The study examined whole blood gene expression in individuals with chronic SCI compared to able-bodied individuals, focusing on differences based on pain status and pain type. Results showed distinct ...
KEY FINDING: Participants with SCI who reported pain had 468 differentially expressed (DE) genes compared to able-bodied (AB) individuals, while those without pain had 564 DE genes.
Journal of Orthopaedic Surgery and Research, 2021 • May 5, 2021
This study analyzed the effects of different analgesics on pain and functional recovery in patients with thoracolumbar fractures. Patients were divided into acetaminophen dihydrocodeine, celecoxib, an...
KEY FINDING: Severe spinal cord injury and peri-treatment use of acetaminophen dihydrocodeine were risk factors for postoperative chronic pain.
JOURNAL OF REHABILITATION MEDICINE, 2020 • August 31, 2020
This study shows that patients with a cervical or thoracic SCI concurrent with signs of damage to LSCR have a lower prevalence of spasticity. As expected, no such association was found for BLSCIN pain...
KEY FINDING: Among 161 patients without damage to the lumbar spinal cord and roots, 87% of those with cervical spinal cord injury experienced spasticity, compared with 85% with thoracic spinal cord injury.
Journal of International Medical Research, 2021 • May 1, 2021
This case report describes a patient who developed SCI after TPI in the left thoracolumbar paraspinal muscles. MRI and electrophysiological studies confirmed the presence of edema/inflammation in the ...
KEY FINDING: The patient experienced an electric shock sensation during the TPI procedure, followed by weakness and neuropathic pain in the left lower extremity.
Neural Plasticity, 2021 • April 13, 2021
This study investigates the effect of LIFU on neuropathic pain (NP) and the expression of potassium chloride cotransporter 2 (KCC2) in the spinal cords of rats with peripheral nerve injury (PNI). The ...
KEY FINDING: LIFU stimulation alleviated mechanical allodynia in PNI model rats, as indicated by increased PWT50 values after 3 weeks of LIFU treatment compared to the LIFU− group.
Neural Plasticity, 2021 • April 19, 2021
The study investigates the role of the Wnt/β-catenin pathway in neuropathic pain (NP) induced by chronic compression of the dorsal root ganglion (DRG). The researchers used a rat model to mimic lumbar...
KEY FINDING: Chronic compression of the DRG leads to changes in the expression of multiple Wnt pathway-related genes and rapid activation of the Wnt/β-catenin pathway in the DRG and spinal cord.
Brain, Behavior, & Immunity - Health, 2020 • July 25, 2020
This study investigated the impact of nerve injury on mood disorders and memory loss, examining the roles of cytokines, growth factors, and glial cells in the process. The researchers induced nerve in...
KEY FINDING: Nerve injury induces depressive-like and anxiety-like behaviors as well as impairment in short-term memory in mice.