Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 391-400 of 682 results
Neuroscience Insights, 2020 • July 29, 2020
This commentary discusses a study using intravital imaging to observe dendritic spine dynamics in the spinal cord before and after nerve injury-induced pain. The study revealed a time-dependent relati...
KEY FINDING: The study revealed a time-dependent relationship between the increase in pain and changes in dendritic spine structure after nerve injury.
Neurosci. Bull., 2020 • September 5, 2020
The study examined the effects of conventional spinal cord stimulation (SCS) on microglial activation in rats with chronic constriction injury (CCI) of the sciatic nerve, a model of neuropathic pain. ...
KEY FINDING: Conventional SCS transiently attenuated mechanical hypersensitivity in rats with chronic constriction injury (CCI) of the sciatic nerve.
International Journal of Molecular Sciences, 2020 • September 7, 2020
This study investigates the mechanisms by which 2 Hz electroacupuncture (EA) alleviates neuropathic pain in spared nerve injury (SNI) rats, focusing on the spinal BDNF/TrκB signaling pathway. The resu...
KEY FINDING: 2 Hz EA significantly down-regulated the levels of BDNF and TrκB mRNA and protein expression in the spinal cord of SNI rats, along with ameliorating mechanical hypersensitivity.
Neurorehabilitation and Neural Repair, 2020 • November 1, 2020
This longitudinal study investigated the evolution of conditioned pain modulation (CPM) over time in patients with spinal cord injury (SCI) and explored its relationship with clinical pain. The study ...
KEY FINDING: A significant decrease in the efficacy of conditioned pain modulation (CPM) was observed over time in patients with SCI.
Molecular Pain, 2020 • January 1, 2020
The study investigates the effects of different spinal cord stimulation (SCS) techniques on cell-specific transcriptomes in a rat model of neuropathic pain. It compares differential target multiplexed...
KEY FINDING: DTMP yielded strong and significant correlations to expression levels found in the healthy animals across every evaluated cell-specific transcriptome.
Top Spinal Cord Inj Rehabil, 2020 • July 1, 2020
The article highlights the importance of primary care providers (PCPs) in managing chronic pain among individuals with spinal cord injury (SCI). It emphasizes the need for PCPs to recognize different ...
KEY FINDING: Chronic pain is highly prevalent among individuals with SCI, significantly affecting their quality of life.
Spinal Cord Series and Cases, 2020 • September 21, 2020
This case report details the effects of spinal cord stimulation (SCS) and rehabilitation on a 48-year-old male with chronic complete L1 paraplegia due to a conus medullaris injury. The patient underwe...
KEY FINDING: Motor ZPPs advanced from L1 to L5 on the left and from L1 to L3 on the right after 18 months of SCS and physical therapy.
International Journal of Surgery Case Reports, 2020 • October 25, 2020
This case report describes a rare instance of cauda equina syndrome following a caudal epidural sacral injection in a 63-year-old male with severe lumbar spinal stenosis. The patient presented with mo...
KEY FINDING: Caudal epidural sacral injection in a patient with severe lumbar spinal stenosis resulted in cauda equina syndrome immediately after the procedure.
Spinal Cord Series and Cases, 2020 • October 17, 2020
This study investigates the effects of transcranial direct current stimulation (tDCS) on motor cortex excitability (MCE) and pain intensity in individuals with chronic spinal cord injury neuropathic p...
KEY FINDING: Four individuals showed a negative variation of motor cortex excitability (MCE) after tDCS, with two reporting a reduction in pain intensity.
Scientific Reports, 2020 • November 27, 2020
The study compared conventional tonic SCS to four dynamically modulated SCS (TDPs) in a rat model of neuropathic pain, using sub-perception thresholds. Results showed that all SCS patterns except puls...
KEY FINDING: All tested SCS patterns except pulse width modulation significantly reversed mechanical hypersensitivity in rats.