Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 371-380 of 682 results
International Journal of Molecular Sciences, 2020 • January 31, 2020
The study demonstrates that Syt-1 plays a role in the development of neuropathic pain. Electroacupuncture can alleviate neuropathic pain, possibly by suppressing Syt-1 protein expression in the spinal...
KEY FINDING: Syt-1 antibody blockade and siRNA silencing increased pain thresholds in SNI rats.
BMC Neurology, 2020 • February 12, 2020
This case report details a 50-year-old man who developed severe bilateral occipital pain following a fall that resulted in a small central cervical spinal cord injury (SCI) at the C2 level. The patien...
KEY FINDING: The patient experienced severe bilateral occipital pain (at-level neuropathic pain) due to a small central cervical SCI, which is an unusual presentation.
Neuromodulation, 2021 • January 1, 2021
This study investigates the impact of spinal cord stimulation (SCS) on protein expression in the spinal cord of rats with neuropathic pain. The results showed that SCS leads to a significant improveme...
KEY FINDING: SCS significantly improved mechanical sensitivity in animals with neuropathic pain after 48 hours of therapy.
Neural Plasticity, 2020 • March 10, 2020
This study investigated the reorganization of insular subregions in individuals suffering from neuropathic pain (NP) after incomplete spinal cord injury (ISCI) to disclose the underlying mechanism of ...
KEY FINDING: Compared to ISCI individuals without neuropathic pain, those with neuropathic pain showed increased functional connectivity between the left posterior insula and the right cerebellum VIIb and VIII, as well as Brodmann area 37.
Korean J Pain, 2020 • April 1, 2020
The study compared the effects of TENS, SCS, and MA on neuropathic, inflammatory, and non-inflammatory pain models in rats. TENS and SCS were effective in all three pain models, while MA was only effe...
KEY FINDING: TENS and SCS produce similar effects in neuropathic, inflammatory and non-inflammatory muscle pain models.
International Journal of Molecular Sciences, 2020 • March 30, 2020
This study evaluated the analgesic effects of spinal cord stimulation (SCS) on neuropathic pain following spared nerve injury (SNI) in rats, focusing on the role of microglial activation and neuronal ...
KEY FINDING: SCS and minocycline both reduced plantar mechanical hypersensitivity in rats after spared nerve injury (SNI), indicating a reduction in pain sensitivity.
Molecular Pain, 2020 • January 1, 2020
This study investigated the effects of differential target multiplexed programming (DTMP) compared to low-rate (LR) and high-rate (HR) spinal cord stimulation (SCS) on neuropathic pain in rats. Behavi...
KEY FINDING: DTMP significantly reduced both mechanical and thermal hypersensitivity compared to low and high-rate SCS.
Pain Research and Management, 2020 • April 10, 2020
This study investigates the effect of 2 Hz electroacupuncture (EA) on neuropathic pain in rats with spared nerve injury (SNI), focusing on the role of interferon regulatory factor 8 (IRF8) and CX3CRl ...
KEY FINDING: Spared nerve injury (SNI) significantly increased spinal IRF8 and CX3CRl mRNA and protein expression in rats.
The Journal of Neuroscience, 2020 • May 27, 2020
This study used intravital imaging to profile dendritic spine dynamics in the superficial dorsal horn of mice before and after peripheral nerve injury, providing insights into the structural changes a...
KEY FINDING: Peripheral nerve injury leads to increased fluctuations in the length and width of dendritic spines in the dorsal horn neurons.
Molecular Pain, 2020 • April 3, 2020
The study investigates the effect of exercise training on neuropathic pain (NPP) after spinal cord injury (SCI) in rats, focusing on the role of glutamic acid decarboxylase (GAD) and tropomyosin-relat...
KEY FINDING: Spinal cord injury leads to mechanical allodynia and thermal hyperalgesia and altered BDNF expression in rats.