Cellular therapies for treating pain associated with spinal cord injury

Spinal cord injury (SCI) often results in significant disability, diminishing the affected individual's quality of life, and currently lacks a definitive cure. Cell-based therapies show promise in both spinal cord regeneration and alleviating neuropathic pain associated with SCI. This article reviews various cell-based therapy options, their development, therapeutic potential, and clinical trials for spinal cord injury and pain mitigation.

• 1
  Cell-based therapies are emerging as promising therapeutic options for spinal cord regeneration and neuropathic pain mitigation after spinal cord injury.
• 2
  Several clinical studies have explored cellular therapies, including adrenal medullary transplants, MSCs, bone marrow transplants, and olfactory ensheathing cells, with varying degrees of success.
• 3
  The review highlights the potential of stem cell transplantation, particularly hESCs and OECs, for spinal cord regeneration, while cellular therapies also aim to address neuropathic pain through different mechanisms.