Browse the latest research summaries in the field of neuroplasticity for spinal cord injury patients and caregivers.
Showing 131-140 of 153 results
Exp Neurol, 2017 • January 1, 2017
Stroke triggers axonal sprouting in areas connected to the damage, initiating within the first week and involving the growth factor GDF10. This process involves a molecular growth program with coordin...
KEY FINDING: Post-stroke axonal sprouting occurs in mice, rats, primates and humans, suggesting it's a conserved response to brain injury.
Front. Neural Circuits, 2017 • November 6, 2017
Finding a treatment for spinal cord injury (SCI) focuses on reconnecting the spinal cord by promoting regeneration across the lesion site. However, while regeneration is necessary for recovery, on its...
KEY FINDING: Synaptic inputs from individual regenerated axons also matched the properties in unlesioned animals, although this was associated with changes in release parameters.
Front. Neural Circuits, 2018 • March 13, 2018
This study investigates the plasticity of the serotonergic system in turtles after spinal cord injury (SCI). It was hypothesized that SCI may trigger homeostatic changes in serotonergic innervation. T...
KEY FINDING: Spinal cord injury (SCI) in turtles leads to an initial reduction in serotonergic innervation followed by an increase in serotonergic cells caudal to the lesion site after 30 days.
Brain, 2018 • June 14, 2018
This study introduces a novel immune-evasive gene switch (dox-i-ChABC) that enables regulated delivery of ChABC in the injured mammalian spinal cord, providing an experimental tool to control delivery...
KEY FINDING: A novel immune-evasive gene switch (dox-i-ChABC) enables regulated delivery of ChABC in the injured mammalian spinal cord.
Neural Regeneration Research, 2018 • August 1, 2018
The brain's ability to adapt and change, known as neuroplasticity, is crucial for maintaining its biological renaissance. Adult neurogenesis, the generation of new neurons in the adult brain, is a key...
KEY FINDING: Adult neurogenesis occurs not only in the hippocampus and SVZ but also in other brain regions like the cortex, amygdala, hypothalamus, and striatum, which are associated with the limbic system and basal ganglia.
Neural Regen Res, 2019 • January 1, 2019
This review examines the differences in neuroplasticity following spinal cord injury (SCI) among animal models and humans, highlighting variations in sensorimotor pathways and recovery rates. It discu...
KEY FINDING: Rats regain weight-bearing abilities without interventions two weeks post-injury, unlike humans.
JOURNAL OF NEUROTRAUMA, 2019 • June 15, 2019
This study investigates the potential of chondroitinase ABC (ChABC) to enhance plasticity and recover respiratory motor function after severe midcervical contusion injury in rats. The key finding is t...
KEY FINDING: ChABC treatment at chronic stages post-cervical contusion injury leads to recovery of normal activity in the ipsilateral hemidiaphragm.
The Journal of Neuroscience, 2019 • June 12, 2019
This study investigates the molecular changes in the spinal cord after cortical stroke in mice, focusing on factors that influence the reinnervation process by contralesional corticospinal neurons. Th...
KEY FINDING: The spinal transcriptome after cortical stroke is characterized by two phases: an early inflammatory phase and a late tissue repair phase with upregulated genes related to neurite outgrowth.
J. Exp. Med., 2019 • November 4, 2019
This study investigates how neuronal circuits remodel after spinal cord injury, focusing on the role of neuronal activity in target selection during corticospinal tract (CST) rewiring. The researchers...
KEY FINDING: NMDAR signaling and CREB-mediated transcription are essential for maintaining nascent corticospinal tract (CST)–relay neuron contacts during circuit remodeling after spinal cord injury.
JOURNAL OF NEUROTRAUMA, 2020 • February 1, 2020
The study investigates the effect of a PTPr inhibitory peptide on respiratory neuronal plasticity and functional restoration using a rat model of C2 hemisection SCI. The PTPr peptide was applied local...
KEY FINDING: PTPr peptide significantly improved ipsilateral hemidiaphragm function, as assessed in vivo with electromyography recordings.