Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,341-5,350 of 5,401 results
Brain, 2010 • September 17, 2010
The study introduces a novel mouse model of CNS demyelination achieved through cell-specific activation of diphtheria toxin A (DT-A) expression in adult oligodendrocytes. This leads to widespread olig...
KEY FINDING: The study successfully generated a mouse model with inducible oligodendrocyte ablation in adulthood, leading to demyelination.
Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2010 • March 1, 2010
The review discusses the challenges of nerve injuries and the limitations of axon regeneration in the central nervous system (CNS) and peripheral nervous system (PNS). It explores two main strategies ...
KEY FINDING: Nanomaterials can support axon regeneration by providing artificial constructs that replace the inhibitory environment in the CNS and PNS.
Brain Res, 2010 • April 6, 2010
This study investigates how diffuse traumatic brain injury (TBI) affects the activation and reorganization of the whisker-barrel circuit in rats. The researchers hypothesized that the extent of functi...
KEY FINDING: Whisker somatosensory regions of the cortex and thalamus maintained cellular composition as visualized by Nissl stain.
BMC Neuroscience, 2010 • February 18, 2010
The study aimed to use RNAi to knock down Semaphorin receptors Npn-1 and Npn-2 in spinal nerve tracts to promote axon regeneration after spinal cord injury. Effective shRNAs were developed to knock do...
KEY FINDING: shRNAs can effectively knock down Npn-1 and Npn-2 expression in neuronal cell lines in vitro using lentiviral delivery.
JOURNAL OF NEUROTRAUMA, 2014 • September 15, 2014
This study demonstrates that FGF-2 administration into the spinal cord dramatically enhanced locomotor functional recovery after complete transection of the spinal cord in rats. The FGF-2-enhanced rec...
KEY FINDING: FGF-2 injection markedly improved locomotor function in rats after complete spinal cord transection.
Neuron, 2010 • March 11, 2010
This study demonstrates that miRNAs, particularly miR-219 and miR-338, are critical regulators of oligodendrocyte differentiation and myelination in the vertebrate CNS. The research shows that miRNAs ...
KEY FINDING: Deletion of Dicer1, an enzyme essential for miRNA processing, in oligodendrocyte lineage cells leads to severe myelination deficits in mice.
PLoS ONE, 2010 • March 16, 2010
This study demonstrates that RNA aptamers can be selected to bind the Nogo-66 receptor (NgR) and compete with myelin-derived inhibitors of axon regeneration for binding to the receptor. Neurite outgro...
KEY FINDING: RNA aptamers can be generated that bind with high affinity to NgR.
Neurosci Bull, 2010 • April 1, 2010
This study investigates the role of PKC in neurite outgrowth of spinal cord neurons in vitro. The researchers found that changes in m/c-PKC activity and PKC-βII expression were significantly correlate...
KEY FINDING: The ratio of membrane-bound PKC activity to cytoplasmic PKC activity (m/c-PKC) and PKC-βII expression in neurites were significantly correlated with neurite outgrowth.
The Journal of Neuroscience, 2010 • March 31, 2010
This study addresses the challenge of limited axon regeneration after CNS injury due to myelin and glial scar inhibition. A chemical screen of a novel triazine library identified four compounds that o...
KEY FINDING: A chemical screen identified four novel triazine compounds (A05, C05, F05, and H08) that overcome myelin-mediated inhibition of neurite outgrowth.
J Clin Immunol, 2010 • May 1, 2010
The study identifies natural human IgM antibodies that can promote remyelination in animal models of demyelinating diseases like multiple sclerosis (MS). These antibodies bind to oligodendrocytes and ...
KEY FINDING: Two human IgMs (sHIgM22 and sHIgM46) were identified that promoted significant remyelination in TMEV-infected mice, suggesting potential therapeutic applications.