Neurology Research

KEY FINDING: ChABC treatment digests CSPGs within a chronic scar, which promotes behavioral recovery after chronic SCI.

KEY FINDING: Transplantation of BDNF-hMSCs resulted in improved locomotor recovery compared to hMSC transplantation alone.

KEY FINDING: Adult zebrafish spinal cord contains ependymoradial glial cells that retain transcription factor expression of the embryonic pMN zone.

KEY FINDING: Glial scar tissue and reactive astrocyte-conditioned medium promote OECs migration in vitro.

KEY FINDING: NA axons are present throughout the caudal stump of both media- and OEG-injected spinal rats, entering the spinal cord from the periphery via dorsal and ventral roots and along large penetrating blood vessels.

KEY FINDING: There were significant increases in MHC-II and ERK1/2 immunoreactivity in the lateral corticospinal tract (LCST) of the cervical spinal cord up to 12 months post-lesion, indicating long-term microglial activation.

KEY FINDING: Recovery of dexterous movements from isolated lateral frontal injury is accompanied by selective contralateral terminal axon sprouting and bouton proliferation that is restricted to spinal laminae VII and IX.

KEY FINDING: Daidzein was identified as a transcriptional inducer of Arg1 through a chemical screen of clinically approved drugs.

KEY FINDING: The study quantitatively demonstrates a novel time-dependent multiphasic response of cellular inflammation in the spinal cord after spinal cord injury.

KEY FINDING: EphA4 expression is primarily associated with astrocytes in the spinal cord and neurons in the cerebral cortex before and after SCI.