Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,321-5,330 of 5,401 results
Neuron, 2009 • October 29, 2009
This study demonstrates that bridging axonal regeneration can be achieved in the adult CNS even when treatments are initiated at extended delays after spinal cord injury (SCI). Effective regeneration ...
KEY FINDING: Combinatorial therapies (peripheral nerve conditioning lesions, grafts of marrow stromal cells, and NT-3 gradients) promote axonal regeneration into and beyond a mid-cervical lesion site, even when administered 6 weeks to 15 months after SCI.
Stem Cells, 2010 • January 1, 2010
This study demonstrates that human embryonic stem cell-derived oligodendrocyte progenitor cells (hESC-derived OPCs) can provide at-level benefit to cervical spinal cord injury (SCI). Transplantation o...
KEY FINDING: Transplanted hESC-derived OPCs survived, localized to the injury site, and differentiated into mature oligodendrocytes.
PNAS, 2010 • February 23, 2010
This study addresses the challenge of delivering chABC, an enzyme that promotes nerve regeneration after spinal cord injury, by thermostabilizing it with trehalose and using a hydrogel-microtube syste...
KEY FINDING: Trehalose significantly enhances the thermal stability of chABC, allowing it to remain active at 37 °C for up to 4 weeks in vitro.
Frontiers in Molecular Neuroscience, 2009 • October 30, 2009
Loss of respiratory function is one of the leading causes of death following spinal cord injury. With the emergence of new and powerful tools from molecular neuroscience, new therapeutically relevant ...
KEY FINDING: Pharmacological intervention which can increase central respiratory drive might be a potential way to induce recovery of the ipsilateral hemidiaphragm following C2 hemisection – without contralateral phrenicotomy.
JBC Papers in Press, 2009 • November 9, 2009
This study investigates the role of neuronal Nogo-A in axonal regeneration, finding that its expression increases after axonal injury and exposure to myelin. The research demonstrates that disrupting ...
KEY FINDING: Neuronal Nogo-A expression increases after axonal injury and exposure to myelin.
J Neurochem, 2013 • February 1, 2013
Neuromodulation aims to correct faulty neural networks by restoring functional neural activity. It requires knowledge of neurons and glia, and understanding of electrical and chemical communication. T...
KEY FINDING: Water-dispersible carbon nanotubes can modulate neurite outgrowth in culture and aid regeneration after spinal cord injury in vivo.
J Neurosci Res, 2010 • May 1, 2010
The study investigates the potential of neural restricted precursors (NRP) and glial restricted precursors (GRP) to generate specific neuronal phenotypes in the injured spinal cord and extend axons to...
KEY FINDING: NRP/GRP grafts can generate glutamatergic and GABAergic neurons in the injured spinal cord, which are essential for repairing local interneuron circuits damaged by SCI.
J Neuropathol Exp Neurol, 2009 • December 1, 2009
This study investigated the therapeutic potential of olfactory bulb ensheathing glia (OB-OEG) for repairing chronic spinal cord injuries (SCI) in rats. Rats with complete SCI received OB-OEG transplan...
KEY FINDING: OB-OEG transplantation in rats with chronic SCI led to progressive improvement in motor function.
PNAS, 2009 • December 8, 2009
This study characterizes a system-wide infiltration of macrophages in the PNS of mutant SOD1 mice that accompanies axon degeneration in ventral roots, sciatic nerves, and muscle tissues. The origin an...
KEY FINDING: Macrophages are activated throughout the PNS in mutant SOD1G93A and SOD1G37R transgenic mouse models of ALS.
JoVE, 2009 • January 1, 2009
One of the goals of our research is to promote axon regeneration to restore connectivity across the lesion site. Importantly, the peripheral nerve grafting approach is effective in promoting regenerat...
KEY FINDING: Ascending and descending spinal axons will enter the graft, grow in a relatively straight line parallel to the length of the graft and extend to the distal end of the graft at a rate of approximately 1 mm per day.