Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,311-5,320 of 5,401 results
The Journal of Neuroscience, 2009 • August 12, 2009
This study investigates how to prevent macrophage-induced retraction of dystrophic adult sensory neurons after CNS injury, using an in vitro model of the glial scar. The researchers found that proteas...
KEY FINDING: General inhibition of matrix metalloproteinases and specific inhibition of MMP-9 prevented macrophage-induced axonal retraction.
Exp Neurol, 2010 • May 1, 2010
This study demonstrates that overexpression of NGF distal to a nerve bifurcation enhances the accuracy of sensory axon reinnervation following nerve transection in a rat femoral nerve model. The enhan...
KEY FINDING: NGF overexpression significantly increased the accuracy of saphenous branch axon reinnervation to the appropriate nerve branch.
J Neurosci Res, 2010 • February 1, 2010
This study investigates the effect of immediate anti-TNF-α (etanercept) therapy on nerve regeneration after sciatic nerve crush injury in rats. The researchers found that TNF-α mRNA expression increas...
KEY FINDING: TNF-α mRNA expression is induced at 1 day and returned to baseline at 5 days after injury in nerve and the corresponding dorsal root ganglia (DRG).
The Journal of Clinical Investigation, 2009 • October 1, 2009
This study demonstrates that B cells, through antibody production, negatively impact recovery after spinal cord injury (SCI) in mice. Mice lacking B cells exhibit improved locomotor function and reduc...
KEY FINDING: Mice lacking B cells showed improved locomotor recovery and reduced lesion volume compared to wild-type mice after spinal cord injury.
J Neurosci Res, 2010 • March 1, 2010
This study investigated the use of x-ray diffraction (XRD) as a rapid method to assess myelin integrity in fixed CNS tissues, aiming to aid research on de- and remyelination in spinal cord injury and ...
KEY FINDING: Fixation introduces variation in myelin periodicity and amount. The range in myelin periodicity (155–190 Å) and the broadened x-ray reflections show fixation-dependent effects.
Molecular Therapy, 2010 • January 1, 2010
This study investigated the potential of PSA and HNK-1 mimetics to promote regeneration and functional recovery after spinal cord injury in mice. The mimetics were delivered via subdural infusions usi...
KEY FINDING: Treatment with PSA mimetic, alone or in combination with HNK-1 mimetic, improved functional outcome of compression spinal cord injury compared with the control treatment.
Science, 2009 • October 23, 2009
Chondroitin sulfate proteoglycans (CSPGs) present a barrier to axon regeneration. However, no specific receptor for the inhibitory effect of CSPGs has been identified. We showed that a transmembrane p...
KEY FINDING: PTPσ binds with high affinity to neural CSPGs. Binding involves the chondroitin sulfate chains and a specific site on the first immunoglobulin-like domain of PTPσ.
Nat Neurosci, 2009 • November 1, 2009
This study identifies GPR17 as a negative regulator of oligodendrocyte differentiation and myelination. Sustained expression of GPR17 inhibits oligodendrocyte maturation, while GPR17 deletion accelera...
KEY FINDING: GPR17 is restricted to oligodendrocyte lineage cells but downregulated during the peak period of myelination and in adulthood.
Retrovirology, 2024 • May 10, 2024
This study investigates the impact of two HIV-1 strains (HIV-1JR-CSF and HIV-1CH040) on CNS pathology in humanized mice, focusing on neuronal injury and neuroinflammation across various brain regions ...
KEY FINDING: HIV-infected human cells were found in the brains of HIV-infected BLT mice, confirming HIV neuroinvasion.
Nat Neurosci, 2009 • November 1, 2009
The study demonstrates that Mst3b mediates the effects of trophic factors in stimulating axon outgrowth in adult RGCs and DRG neurons. Mst3b exerts its effects through changes in its kinase activity. ...
KEY FINDING: Mst3b mediates the axon-promoting effects of trophic factors in mature rat retinal ganglion cells (RGCs) and dorsal root ganglion (DRG) neurons.