Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,271-5,280 of 5,401 results
TISSUE ENGINEERING: Part A, 2009 • July 1, 2009
The study investigates the use of biodegradable polymer scaffolds loaded with neural stem cells (NSCs) and Schwann cells (SCs) to promote axonal regeneration in a rat model of complete spinal cord tra...
KEY FINDING: Biodegradable scaffolds seeded with NSCs or SCs facilitate regeneration across the transected spinal cord.
Exp Neurol, 2009 • May 1, 2009
This study investigates the expression of myelin inhibitors Nogo-A and MAG during oligodendrogliogenesis and their effects on neurite outgrowth. The findings reveal that OPCs express Nogo-A but not MA...
KEY FINDING: OPCs express the intracellular domain of Nogo-A but not MAG, while mature oligodendrocytes express both.
Molecular Therapy, 2009 • June 1, 2009
This study investigates a combination of microsurgery and gene therapy to repair spinal dorsal root injuries, common in brachial plexus injuries. Microsurgery restores anatomical continuity, while gen...
KEY FINDING: Microsurgery combined with gene therapy promotes efficient axonal regrowth of DR ganglion central axons into the spinal cord.
Exp Neurol, 2009 • June 1, 2009
This study investigates the expression of RGM and its receptor neogenin in the sea lamprey spinal cord after injury. It aims to understand their roles in axon regeneration, which occurs in lampreys bu...
KEY FINDING: RGM mRNA is expressed in the spinal cord of sea lampreys, primarily in neurons of the lateral gray matter and dorsal cells.
Aging Cell, 2009 • April 1, 2009
This study characterized myelin changes within the murine rubrospinal tract and found that internode lengths significantly decrease as a function of age which suggests active remyelination. The data r...
KEY FINDING: Internode lengths of rubrospinal tract axons significantly decrease with age, suggesting active remyelination.
PNAS, 2009 • April 28, 2009
The study investigates methods to induce regeneration of corticospinal axons, which are crucial for motor function but typically do not regenerate after injury. The researchers hypothesized that enhan...
KEY FINDING: Overexpression of trkB in layer V motor cortex in vivo induces axonal regeneration after subcortical axotomy.
Curr Biol, 2009 • June 9, 2009
The mammalian CNS typically does not regenerate well after injury. However, prior research showed that a 'conditioning lesion' to peripheral axons of dorsal root ganglion (DRG) neurons can promote reg...
KEY FINDING: DRG neurons can be conditioned peripherally even after a central lesion has occurred, upregulating regeneration-associated genes (RAGs) similarly to conditioning before CNS injury.
TISSUE ENGINEERING: Part A, 2009 • November 1, 2009
This study investigates the host response to porous multiple channel bridges implanted in a rat spinal cord hemisection model, focusing on the distribution and organization of cells within the bridge....
KEY FINDING: Multiple channel bridges support cellular infiltration, creating a permissive environment for neural fiber growth.
The Journal of Neuroscience, 2009 • April 29, 2009
This study demonstrates that α9 integrin expression promotes neurite outgrowth on tenascin-C (TN-C) both in vitro and in vivo, suggesting a potential therapeutic strategy for enhancing axon regenerati...
KEY FINDING: Expression of α9 integrin in PC12 cells and adult rat DRG neurons promotes extensive neurite outgrowth on tenascin-C in vitro.
Acta Biomater., 2009 • September 1, 2009
This study examined the effect of scaffold channel size on axonal regeneration in transected rat spinal cords using Schwann cell-seeded PLGA scaffolds. The study found that smaller diameter channels (...
KEY FINDING: Scaffolds with 450-μm channels had significantly more axon fibers per channel than 660-μm scaffolds at 1 and 3 months post-implantation.