Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,261-5,270 of 5,401 results
Exp Neurol, 2009 • March 1, 2009
This study developed an in vitro model to examine the ability of olfactory bulb-derived OEG to promote axon regeneration of DRG neurons on a myelin substrate. The results showed that OEG promote a hig...
KEY FINDING: OEG enhance DRG axon outgrowth on myelin: More neurons generate axons, and their average length is almost twice that of those grown on myelin alone.
J Comp Neurol, 2009 • March 1, 2009
This study characterized SPRR1A expression in the DRG and spinal cord of adult mice following injury to the peripheral and central projections of DRG neurons, finding that SPRR1A induction correlates ...
KEY FINDING: SPRR1A expression is minimal following injury to the centrally projecting branches of DRG neurons.
JOURNAL OF NEUROTRAUMA, 2009 • March 1, 2009
Mild to moderate hypothermia has shown promise in protecting the brain and spinal cord after injury in animal models. The mechanisms behind hypothermic protection involve various cellular, biochemical...
KEY FINDING: Mild hypothermia can improve functional outcomes in transient global ischemia models, including sensorimotor and cognitive functions.
JOURNAL OF NEUROTRAUMA, 2009 • January 1, 2009
This study demonstrates that ibuprofen promotes recovery from spinal cord contusion through a complex mechanism including axonal sprouting, neuroprotection, and raphespinal regeneration. Ibuprofen tre...
KEY FINDING: Ibuprofen reduces ligand-induced Rho signaling and myelin-induced inhibition of neurite outgrowth in vitro.
BioMed Central, 2009 • January 6, 2009
This study demonstrates that the sea cucumber Holothuria glaberrima can fully regenerate its radial nerve cord (RNC) after transection, restoring its morphology and cellular composition within a month...
KEY FINDING: Holothuria glaberrima can regenerate its radial nerve cord within a month following transection.
J Biomed Mater Res A, 2010 • January 1, 2010
This study investigates the effects of fibrin scaffolds on subacute rat spinal cord injury (SCI). Fibrin scaffolds were implanted two weeks post-injury to evaluate neural fiber sprouting and migration...
KEY FINDING: Fibrin scaffolds significantly increased neural fiber staining in the lesion site at 2 and 4 weeks after treatment compared to untreated controls.
Glia, 2009 • August 15, 2009
This study investigates the effects of GDNF on axonal regeneration and myelination following SCI, focusing on whether GDNF acts directly on neurons or indirectly through SCs. The results indicate that...
KEY FINDING: GDNF enhances both the number and caliber of regenerated axons in vivo and increases neurite outgrowth of dorsal root ganglion neurons (DRGN) in vitro, suggesting that GDNF has a direct effect on neurons.
The Journal of Neuroscience, 2009 • March 25, 2009
This study demonstrates that activated macrophages can simultaneously promote axon regeneration and neurotoxicity in the CNS. Zymosan-activated macrophages (ZAMs) initially enhance axon growth towards...
KEY FINDING: Activated macrophages (ZAMs) increase axon growth towards macrophage foci in the spinal cord, indicating a pro-regenerative effect.
Neuroimage, 2009 • May 1, 2009
This study investigated the use of quantitative MRI techniques (qT2 and MTR) to assess demyelination and remyelination in a mouse model of multiple sclerosis. Lysolecithin was injected into the spinal...
KEY FINDING: The myelin water fraction (MWF) and geometric mean T2 value significantly decreased at 14 days post-injection, indicating demyelination. By 28 days, these values returned to control levels, suggesting remyelination.
The Journal of Neuroscience, 2009 • January 28, 2009
This study demonstrates that the EGF receptor, when activated in astrocytes, triggers a signaling pathway involving Akt, Tuberin, Rheb, and mTOR. The research also shows that this pathway is functiona...
KEY FINDING: EGF activates the mTOR pathway in cultured adult spinal cord astrocytes through Akt-mediated phosphorylation of Tuberin, leading to Rheb activation.