Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,191-5,200 of 5,401 results
The Journal of Neuroscience, 2007 • August 15, 2007
This study demonstrates that spinal cord injury (SCI) induces microglial activation in the ventral posterolateral (VPL) nucleus of the thalamus, a brain region involved in pain processing. The chemoki...
KEY FINDING: CCL21 is upregulated in dorsal horn neurons and tissue levels are increased in the dorsal horn and VPL nucleus of the thalamus 4 weeks after SCI.
Exp Neurol, 2007 • October 1, 2007
This study investigates the therapeutic potential of utilizing neurotrophin-transduced Schwann cells (SCs) to repair the injured spinal cord in a rat model of contusion. Schwann cells were transduced ...
KEY FINDING: D15A-secreting SC grafts exhibited 5-fold increases in graft volume, SC number and myelinated axon counts and a 3-fold increase in myelinated to unmyelinated (ensheathed) axon ratios.
Exp Neurol, 2008 • February 1, 2008
The failure of axons to regenerate after spinal cord injury remains a significant challenge, but advances have been made in identifying inhibitory proteins in CNS myelin. Elevation of intracellular cA...
KEY FINDING: Elevation of intracellular cAMP levels promotes axonal regeneration in the CNS, overcoming myelin inhibition both in vitro and in vivo.
Cell Mol Neurobiol, 2007 • September 19, 2007
The study investigates changes in cAMP levels in the developing opossum spinal cord during the critical period when regeneration stops being possible. Endogenous cAMP levels were measured in tissue ho...
KEY FINDING: A significant decrease in cAMP levels was observed during the period when the opossum spinal cord loses its regenerative capability.
Eur Spine J, 2007 • September 21, 2007
The study aimed to evaluate the efficacy of adenovirus vector-mediated BDNF ex vivo gene transfer to BMSC in adult rats with completely transected spinal cords. The results showed that BMSC transplant...
KEY FINDING: Adenovirus vector-mediated ex vivo gene transfer of BDNF to BMSC enhances axonal regeneration in completely transected spinal cord.
The Journal of Neuroscience, 2007 • September 26, 2007
This study investigated whether transient delivery of growth factors could sustain regenerated axons after spinal cord injury (SCI). The researchers used a tetracycline-inducible system to control BDN...
KEY FINDING: Transient growth factor delivery is sufficient to sustain long-term axonal projections into a site of SCI.
BMC Neuroscience, 2007 • September 27, 2007
The study investigated axonal regeneration in NG2 knockout mice compared to wild-type controls after injuries to the CNS (corticospinal tract, dorsal column, dorsal root) and PNS (sciatic and facial n...
KEY FINDING: NG2 deficiency did not enhance regeneration of corticospinal tract axons after spinal cord injury.
Exp Neurol, 2008 • February 1, 2008
The review discusses the progress in understanding the mechanisms behind successful axonal regeneration in the peripheral nervous system and the failure of regeneration in the central nervous system. ...
KEY FINDING: Adult axons retain sensitivity to growth factors, and patterns of growth factor sensitivity after injury in adulthood recapitulate developmental patterns.
Cellular and Molecular Life Sciences, 2008 • November 3, 2007
Investigations into mechanisms that restrict the recovery of functions after an injury to the brain or the spinal cord have led to the discovery of specific neurite growth inhibitory factors in the ad...
KEY FINDING: Neutralizing Nogo-A promotes axonal regeneration of various types of CNS neurons.
Cell. Mol. Life Sci., 2008 • November 20, 2007
Significant spinal cord regeneration following injury is not observed in any adult higher vertebrates (amniotes), but can occur in some lower vertebrates (anamniotes) such as tailed amphibians and fis...
KEY FINDING: Clearwaters reported regeneration in the embryonic spinal cord, but lack of regeneration and extensive scarring in the postnatal spinal cord.