Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,181-5,190 of 5,401 results
Glia, 2007 • May 1, 2007
This study examined the role of Myt1, a transcription factor, in oligodendrocyte regeneration and remyelination in both rodent and human CNS demyelinated lesions. The MHV model was used to induce spin...
KEY FINDING: The density of Myt1 expressing cells markedly increased in lesioned areas of spinal cord white matter in MHV-infected mice, peaking during early remyelination.
PNAS, 2007 • March 13, 2007
The study identifies pleiotrophin (PTN) as a neurotrophic factor upregulated in denervated distal nerve and muscle. Exogenous PTN enhances axonal regeneration and protects facial motor neurons from tr...
KEY FINDING: PTN mRNA is upregulated in denervated Schwann cells and muscle after axotomy, peaking at 7 days and returning to baseline by 3 months.
PLoS Medicine, 2007 • April 10, 2007
The study investigates the potential of TREM2-transduced myeloid precursor cells to mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis (EAE). Resu...
KEY FINDING: TREM2-transduced myeloid cells migrated to inflammatory lesions in the spinal cord of EAE mice.
The Journal of Neuroscience, 2007 • April 11, 2007
This study identifies that the nonsteroidal anti-inflammatory drugs (NSAIDs) ibuprofen and indomethacin overcome neuronal growth inhibitions from CNS myelin and CSPGs via repressing the activity of in...
KEY FINDING: Ibuprofen and indomethacin reverse RhoA activation induced by CNS myelin, CSPGs, or spinal cord lesion.
J Comp Neurol, 2007 • June 20, 2007
This study demonstrates that proximally axotomized spinal interneurons have the potential to form new connections via de novo axons from distal dendrites. A second set of CINs that were proximally axo...
KEY FINDING: Nearly half of the spinal commissural interneurons (CINs) had de novo axons that emerged from distal dendrites after axotomy.
Glia, 2007 • July 1, 2007
This study investigates the potential of exercise to overcome the inhibitory effects of myelin on neuronal growth in the central nervous system. The findings demonstrate that exercise reduces the inhi...
KEY FINDING: Exercise reduces the levels of myelin-associated glycoprotein (MAG) in the spinal cord, a potent axonal growth inhibitor.
The Journal of Neuroscience, 2007 • May 30, 2007
The study investigates targeting regenerating sensory axons to normal synaptic locations in the spinal cord by combining positive and negative guidance molecules. NGF and semaphorin 3A treatment also ...
KEY FINDING: NGF overexpression leads to robust regeneration and sprouting of CGRP-positive nociceptive axons throughout the dorsal and ventral horns.
Radiation Oncology, 2007 • June 30, 2007
The review summarizes experimental strategies for preventing and treating radiation-induced CNS toxicity, including neurocognitive decline and radiation necrosis, highlighting the importance of tailor...
KEY FINDING: Early intervention with agents like amifostine and growth factors (IGF-1, FGF-2) shows preliminary evidence of modulating the radiation response in the CNS and increasing long-term radiation tolerance.
The Journal of Neuroscience, 2007 • July 4, 2007
This study demonstrates that Schwann cells (SCs) and olfactory ensheathing cells (OECs) differentially interact with astrocytes, influencing astrocytosis following CNS injury. SC-conditioned media (SC...
KEY FINDING: Schwann cell-conditioned media induces reactive astrocytosis and boundary formation in OEC/astrocyte cocultures, sensitive to FGFR1 inhibition.
The Journal of Neuroscience, 2007 • July 25, 2007
This study investigates the role of ATF3, a transcription factor induced by peripheral nerve injury, in promoting nerve regeneration. The researchers generated transgenic mice that constitutively expr...
KEY FINDING: ATF3 enhances the rate of peripheral nerve regeneration to an extent comparable to a preconditioning nerve injury.