Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,171-5,180 of 5,401 results
J Neurobiol, 2006 • December 1, 2006
This study demonstrates that the mechanism of axon regeneration undergoes a developmental switch between E7 and E14 from strict dependence on F-actin to a greater dependence on microtubule polymerizat...
KEY FINDING: Early embryonic (E7) sensory axons strictly require F-actin for axon maintenance and regeneration, whereas later embryonic (E14) axons can extend even in the absence of F-actin.
The Journal of Neuroscience, 2006 • October 25, 2006
The study aimed to understand the mechanisms of OEC migration and axonal guidance after SCI by injecting lamina propria OECs near SCI sites. The findings indicate that OECs form cell tracts that displ...
KEY FINDING: OECs do not exhibit significant migratory properties when grafted to the spinal cord after SCI.
Brain Res., 2006 • December 13, 2006
This study investigates the integration of transplanted olfactory ensheathing cells (OECs) into peripheral nerve injuries, specifically a sciatic nerve crush lesion in rats. The results show that tran...
KEY FINDING: Transplanted OECs survive in the lesion and distribute along regenerated axons in the peripheral nerve.
The Journal of Neuroscience, 2006 • November 22, 2006
This study investigates the role of Nogo-A and its receptor NgR1 in limiting axonal growth in the adult CNS, using a pyramidotomy model to assess CST axon sprouting in nogo-abatg/atg and ngr1-/- mice....
KEY FINDING: In nogo-abatg/atg and ngr1-/- mice, there is significant growth of CST axons into denervated cervical gray matter following pyramidotomy.
Cellular and Molecular Neurobiology, 2007 • December 7, 2006
The injured adult spinal cord is not conducive for neuronal regeneration and neurogenesis. Engrafted neural precursor cells (NPCs) differentiate largely into astroglia, with only a very small percenta...
KEY FINDING: Transplantation of ES cell-derived oligodendrocyte progenitor cells (OPCs) into contusion-injured adult rat spinal cord OPCs can differentiate into oligodendrocytes and improve locomotor ability if transplanted early after injury.
J Biol Chem, 2007 • February 23, 2007
The current study extends our understanding of how myelin inhibitors interact with the NgR family: NgR1 binds three linear segments of Nogo-A as well as MAG and OMgp; mutagenesis defined overlapping N...
KEY FINDING: RTN2 and RTN3 interact with NgR1 with nanomolar affinity, suggesting a role in myelin inhibition of axonal growth.
J Comp Neurol, 2007 • April 1, 2007
This study investigates the expression patterns of netrin, Sema3, and Sema4 in the lamprey spinal cord during regeneration after transection. In control lampreys, netrin was expressed in neurons along...
KEY FINDING: Netrin expression was downregulated in neurons near the spinal cord transection site at 2 and 4 weeks post-injury, suggesting it may be involved in restricting axonal regeneration.
Neuroscience, 2011 • January 13, 2011
This study investigates the role of Sox11b in spinal cord regeneration in adult zebrafish. Microarray analysis revealed that Sox11b mRNA is up-regulated after spinal cord injury, particularly in epend...
KEY FINDING: Sox11b mRNA is up-regulated in ependymal cells lining the central canal and newly differentiating neuronal precursors or immature neurons after spinal cord injury in adult zebrafish.
The Journal of Neuroscience, 2007 • February 28, 2007
This study used transgenic mice expressing chondroitinase ABC (ChABC) to investigate the role of chondroitin sulfate proteoglycans (CSPGs) in limiting axonal regeneration after CNS injury. The researc...
KEY FINDING: Transgenic expression of ChABC allows CST axons to enter scar tissue after dorsal hemisection, but does not significantly improve motor function recovery.
The Journal of Neuroscience, 2007 • February 28, 2007
This study demonstrates a PGE2-dependent, ERK1/2-regulated microglia–neuron signaling pathway that mediates the microglial component of pain maintenance after injury to the spinal cord. The researcher...
KEY FINDING: Phosphorylated ERK1/2 (pERK1/2), an upstream regulator of PGE2 release, is specifically localized to microglial cells in the lumbar dorsal horn after SCI.