Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,141-5,150 of 5,401 results
Eur J Neurosci, 2005 • August 1, 2005
The study investigates the combined effects of methylprednisolone (MP) and soluble Nogo-66 receptor (NgR) on spinal cord injury (SCI) recovery in rats, using a dorsal hemisection model. Both MP and Ng...
KEY FINDING: Combined treatment with NgR(310)ecto-Fc and MP had a more pronounced effect on recovery of function and axonal growth compared with either treatment alone.
The Journal of Neuroscience, 2005 • August 31, 2005
The study investigates strategies to promote sensory axon regeneration in the injured spinal cord, focusing on overcoming inhibitory factors and enhancing neuronal growth capacity. The key finding is ...
KEY FINDING: Inflammation-induced preconditioning of sensory neurons combined with enzymatic degradation of inhibitory proteoglycans (CSPGs) significantly enhances axonal regeneration through the DREZ.
Glia, 2006 • March 1, 2006
This study investigates the neuroprotective effects of olfactory ensheathing cell (OEC) transplantation on corticospinal tract (CST) neurons after dorsal spinal cord transection in rats. The results d...
KEY FINDING: OEC transplantation reduces the number of apoptotic cortical neurons at 1 week post-transplantation.
Eur Spine J, 2006 • November 16, 2005
This study examined glial reactions following spinal cord injury in fetal rats compared to adult rats, focusing on astrocytes and microglia. The findings indicated that fetal rats do not develop scar ...
KEY FINDING: Scar formation was observed in adult rats' spinal cords after injury, but not in fetal rats.
PNAS, 2006 • January 17, 2006
This study demonstrates the role of Cdk5 in nociceptive signaling. It identifies the expression of Cdk5 and its activator p35 in nociceptive neurons and shows that this expression is modulated during ...
KEY FINDING: Cdk5 and p35 are expressed in pain-sensing neurons (nociceptors) within the dorsal root ganglia (DRG), trigeminal ganglia (TG), and spinal cord (SC).
BMC Neuroscience, 2006 • January 12, 2006
The study investigates the expression and function of ZAS3, a zinc finger protein, in the nervous system and its relationship with NF-κB after peripheral nerve injury. Results show that ZAS3 is expres...
KEY FINDING: ZAS3 is expressed in specific regions of the central and peripheral nervous system, including the trigeminal ganglion, hippocampal formation, dorsal root ganglia, and motoneurons.
BMC Neuroscience, 2006 • January 24, 2006
The study investigated the effects of LPS-induced inflammation on the expression of growth-associated genes in corticospinal neurons and the potential for axonal regeneration after spinal cord injury....
KEY FINDING: Application of LPS induced a gradient of inflammation throughout the motor cortex.
The Journal of Neuroscience, 2006 • January 25, 2006
This study investigates the contribution of dorsal progenitors to cortical myelination by ablating Olig2, a key gene for oligodendrocyte specification, in these cells. The results demonstrate that dor...
KEY FINDING: Ablation of Olig2 in dorsal progenitors leads to a near-complete absence of myelination in the cortex during early postnatal stages.
The Journal of Neuroscience, 2006 • February 8, 2006
This study demonstrates that transplanted GFP-OECs can remyelinate demyelinated spinal cord axons and establish structurally intact nodes of Ranvier. The remyelinated axons exhibit appropriate cluster...
KEY FINDING: Transplanted olfactory ensheathing cells (OECs) remyelinate demyelinated axons in the spinal cord and promote the formation of structurally intact nodes of Ranvier.
The Journal of Neuroscience, 2006 • March 29, 2006
This study investigates the potential of adult brain-derived neural precursor cells (NPCs) to promote remyelination and functional recovery after spinal cord injury (SCI) in rats. The researchers tran...
KEY FINDING: Transplanted adult neural precursor cells (NPCs) survived better in the injured spinal cord when transplanted during the subacute phase of injury compared to the chronic phase.