Oxidative Medicine and Cellular Longevity, 2021 · DOI: https://doi.org/10.1155/2021/8253742 · Published: February 10, 2021
This study investigates the role of retinoid X receptor α (RXRα) and p66shc in nerve regeneration after spinal cord injury. The researchers found that RXRα inhibits nerve regeneration after spinal cord injury. They also discovered that RXRα promotes the expression of p66shc, a protein that regulates cell senescence and oxidative stress. This upregulation of p66shc by RXRα contributes to the inhibition of nerve regeneration. The study suggests that targeting RXRα or p66shc could promote functional recovery after spinal cord injury. Specifically, inhibiting RXRα or p66shc promoted functional recovery after spinal cord injury.
Targeting RXRα or p66shc could be a potential therapeutic strategy for promoting nerve regeneration and functional recovery after spinal cord injury.
Development of RXRα antagonists or p66shc inhibitors could lead to new treatments for spinal cord injury.
The study enhances understanding of the molecular mechanisms involved in nerve regeneration after spinal cord injury, providing insights for future research.