Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 311-320 of 5,401 results
PLoS ONE, 2014 • May 15, 2014
This study demonstrates that human adipose-derived stromal cells (hADSCs) improve open field locomotion after spinal cord injury in rats. hADSCs secreted human laminin, accumulating in the spinal cord...
KEY FINDING: hADSCs promote complete recovery of motor function after 8 weeks, while improving tissue preservation, restricting inflammation and stimulating axonal growth.
J Neurosci Methods, 2014 • July 30, 2014
The authors developed a two-compartment organotypic culture platform to study motor axon regeneration after nerve repair. The platform consists of a PDMS base and a collagen-coated membrane. The devel...
KEY FINDING: Motoneurons remain healthy for several weeks within the two-compartment system, demonstrating the viability of the culture.
PNAS, 2014 • May 19, 2014
This study provides the first real-time imaging of transplanted stem cell-mediated remyelination in a mouse model of MS. Using two-photon microscopy and viral-induced demyelination, we describe a tech...
KEY FINDING: NPCs transplanted into spinal cords of JHMV-infected mice exhibited diminished migration velocities and increased proliferation compared with transplanted cells in noninfected mice.
Semin Cell Dev Biol, 2014 • September 1, 2014
Sonic hedgehog (Shh) is a key factor in the developing central nervous system (CNS), influencing proliferation, specification, and axonal targeting. Shh signaling modulates the self-renewal and specif...
KEY FINDING: Shh signaling is essential for the establishment and maintenance of adult neural stem cell niches in the ventricular-subventricular zone (V-SVZ) and subgranular zone (SGZ).
JOURNAL OF NEUROTRAUMA, 2014 • August 1, 2014
The MIASCI draft standard has been proposed to capture SCI experimental details, including the investigator, organism, behavior, surgery, perturbagens, histology, immunohistochemistry, imaging, biomat...
KEY FINDING: Transparent reporting standards for experiments using animal models of human SCI aim to reduce inherent bias and increase experimental value.
The Journal of Neuroscience, 2014 • May 28, 2014
This study investigates the role of astrocyte GLT1 overexpression in a rat model of cervical spinal cord injury (SCI). The results showed that astrocyte-targeted GLT1 overexpression increased lesion s...
KEY FINDING: GLT1 expression in astrocytes decreases following cervical spinal cord injury in mice, persisting for at least 6 weeks.
Exp Neurol, 2014 • November 1, 2014
This study investigated the long-term survival, axonal growth-promotion, and myelination potential of Schwann cells (SCs) grafted into a contused spinal cord in adult rats. The key findings revealed r...
KEY FINDING: Grafted SCs-GFP exhibited remarkable survival up to 24 weeks post-grafting in the contused spinal cord of adult rats.
Neural Plasticity, 2014 • May 4, 2014
The peripartum period is characterized by significant physiological and behavioral adaptations in the maternal body, driven by alterations in neural plasticity. The maternal brain undergoes structural...
KEY FINDING: Peripartum-associated changes in neural plasticity include adult neurogenesis, synaptic plasticity, and dendritic remodeling in various brain regions, essential for fetal development and maternal health.
BMC Neuroscience, 2014 • May 5, 2014
This study investigates the potential of boundary cap neural crest stem cells (bNCSCs) to aid sensory axon regeneration after dorsal root avulsion injury in adult rodents. bNCSCs were implanted into t...
KEY FINDING: Transplanted bNCSCs showed extensive survival and differentiation after transplantation to the avulsed DRTZ.
Journal of Visualized Experiments, 2014 • May 21, 2014
This video article details a method for performing spinal cord transections on larval zebrafish to study regeneration. Unlike mammals, zebrafish exhibit robust recovery after spinal cord injury. The p...
KEY FINDING: The presented method allows for high throughput spinal cord transections in larval zebrafish with low mortality and high reproducibility.