Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 301-310 of 5,401 results
Neuroscience, 2014 • July 11, 2014
The study investigates the functional distinctions between NGF-mediated plasticity and regeneration of nociceptive axons within the spinal cord using a dorsal root entry zone model in rats. NGF-induce...
KEY FINDING: NGF-induced sprouting of CGRP axons in normal animals resulted in a significant redistribution of synapses and cFos expression into the deeper dorsal horn, leading to severe chronic pain.
PLoS ONE, 2014 • April 18, 2014
This study identifies legumain as an essential component for successful spinal cord regeneration in adult zebrafish after complete spinal cord transection. The researchers found that legumain is upreg...
KEY FINDING: Legumain expression is upregulated in neurons of regenerative nuclei (NMLF and IMRF) during axon regrowth/sprouting after spinal cord injury.
The Journal of Neuroscience, 2014 • April 23, 2014
The study demonstrates that peripheral nerve injury induces a global increase in axonal transport, extending to the central branch of DRGs. This increase in axonal transport supports the regeneration ...
KEY FINDING: A peripheral conditioning lesion increases the anterograde transport of cytoskeleton components, metabolic enzymes and axonal regeneration enhancers in the central branch of DRGs.
ADVANCES IN WOUND CARE, 2014 • February 1, 2014
Nervous system injuries, whether in the CNS or PNS, often lead to poor outcomes. Electric fields (EFs) are being explored as a therapeutic approach to enhance nerve regeneration. EFs have demonstrated...
KEY FINDING: Exogenous EFs have shown neuroprotective effects in various eye injury models, including traumatic injury and glaucoma.
Nature, 2014 • May 8, 2014
This study reveals that astrocytes in different regions of the spinal cord are functionally distinct, influencing neural circuit formation and maintenance. Ventral astrocytes produce Sema3a, which is ...
KEY FINDING: Ventral spinal cord astrocytes express region-specific genes, including Semaphorin3a (Sema3a), crucial for sensorimotor circuit organization.
Neural Plasticity, 2014 • March 23, 2014
The study investigated the impact of neonatal sciatic nerve crush on Renshaw recurrent inhibition (RI) in rats. Results showed that MSRs had larger amplitudes and longer latencies after the nerve crus...
KEY FINDING: Neonatal sciatic nerve crush leads to larger amplitude and longer latency of monosynaptic reflexes (MSR) recorded from LG-S and MG nerves.
J. Cell. Mol. Med., 2014 • July 1, 2014
This study investigates the role of TGF-β1 signaling in the adult neurogenic niche, focusing on its impact on neural stem cell quiescence and neuronal differentiation. The research demonstrates that T...
KEY FINDING: TGF-b1 signalling in the adult neurogenic niche contributes to stem cell quiescence, and to neuronal differentiation, maturation and survival of newly generated cells.
Neuroscience, 2014 • December 26, 2014
Acute brain injuries cause rapid cell death that activates bidirectional crosstalks between the injured brain and the immune system. Here we have reviewed the available information about the role and ...
KEY FINDING: Early immune activation after acute CNS injury might have neuroprotective effects.
Stem Cell Rev and Rep, 2014 • May 8, 2014
This study investigates the guided migration of embryonic stem cell (ESC) derived presumptive motor neurons in an applied electric field (EF). The results showed that neural precursors migrated toward...
KEY FINDING: Neural precursors migrated toward the cathode pole of applied electric fields.
Neurosci Bull, 2014 • August 1, 2014
This review summarizes recently-completed clinical trials using cell-mediated regenerative therapies for human SCI, together with ongoing trials using neural stem cells. Specifically, clinical studies...
KEY FINDING: Current transplantation therapies are relatively safe and have provided varying degrees of neurological recovery in SCI patients.