Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 181-190 of 5,401 results
The Journal of Neuroscience, 2013 • January 2, 2013
This study identifies TRPC1 subunit-containing channels as mechanosensitive (MS) channels on spinal neuron growth cones. Increasing or decreasing MS channel activity alters axon outgrowth by influenci...
KEY FINDING: TRPC1 subunits assemble mechanosensitive channels on Xenopus neuronal growth cones, regulating axon outgrowth on rigid substrates.
PLoS ONE, 2012 • December 21, 2012
This study investigates the role of contactin-2 in spinal cord regeneration in adult zebrafish, finding that its expression is upregulated after injury. Using morpholino-mediated knockdown, the resear...
KEY FINDING: Contactin-2 mRNA and protein levels are upregulated along the central canal after spinal cord injury in adult zebrafish, suggesting a role in regeneration.
Int. J. Biol. Sci., 2013 • December 22, 2012
The study investigates the therapeutic potential of transplanting glial-restricted precursor-derived astrocytes (GDAs) expressing the neurotrophin D15A into rats with spinal cord injuries (SCI). The r...
KEY FINDING: Transplantation of D15A-GDAs significantly increased the spared white matter and decreased the injury size compared to control groups.
Biomaterials, 2013 • March 1, 2013
This study investigates the impact of channel density and porosity in PLG bridges on neurite extension in rat and mouse spinal cord injury models. The findings demonstrate that bridges with higher por...
KEY FINDING: Increasing bridge porosity substantially increased the number of axons, correlating with the extent of cell infiltration throughout the bridge.
JOURNAL OF NEUROTRAUMA, 2013 • May 15, 2013
This study shows the pattern of Ryk receptor expression in the unlesioned adult spinal cord, in neurons (mainly in the ventral horns), astrocytes close to the pial surface, and blood vessels. We also ...
KEY FINDING: Ryk mRNA expression increased from 24 hours post-injury until 7 days post-injury.
PLoS ONE, 2013 • January 21, 2013
This study provides evidence that agmatine treatment leads to lasting improvements of structure and function after spinal cord injury (SCI). Agmatine modulates BMP-2/4/7 expressions in neurons, oligod...
KEY FINDING: Agmatine treatment improved locomotor recovery and bladder function in mice with SCI.
Eur J Neurosci, 2013 • April 1, 2013
The study demonstrates that electrical stimulation of the motor cortex promotes significant axon outgrowth to the spinal cord, red nucleus, and cuneate nucleus after unilateral pyramidotomy in rats. S...
KEY FINDING: Electrical stimulation of the motor cortex after spinal cord injury increases axon length in both the spinal cord and magnocellular red nucleus.
Adv Funct Mater, 2010 • May 10, 2010
This study developed nanofibrous scaffolds with aligned nanofibers for nerve guidance and drug delivery in spinal cord. The scaffolds with rolipram increased axon growth through the scaffolds and in t...
KEY FINDING: Scaffolds with rolipram significantly improved hindlimb function after 3 weeks in rats with spinal cord injury.
J Hand Surg Am, 2013 • March 1, 2013
The study evaluated the effectiveness of a supercharge end-to-side (SETS) nerve transfer in augmenting recovery from incomplete nerve injuries in a rat model. The SETS procedure was performed in conju...
KEY FINDING: SETS transfer significantly increased myelinated axonal counts in the distal tibial nerve compared to the IRM and SETS groups at 5 and 8 weeks.
PNAS, 2013 • March 5, 2013
This study used a transgenic mouse model to visualize and quantify spontaneously regenerated myelin after spinal cord injury, distinguishing it from pre-existing myelin. The research challenges the as...
KEY FINDING: OL-regenerated sheaths elongated progressively over 6 mo to approach control values.