Browse the latest research summaries in the field of mental health for spinal cord injury patients and caregivers.
Showing 281-289 of 289 results
Neurobiology of Stress, 2024 • May 15, 2024
This study investigated whether coffee polyphenols could protect against early-life stress (ES)-induced cognitive deficits in male mice. ES was induced via limited nesting and bedding, and mice were g...
KEY FINDING: Coffee polyphenol supplementation early in life protected against ES-induced later life cognitive deficits, as evidenced by improved performance in object recognition and spatial memory tasks.
The Journal of Spinal Cord Medicine, 2015 • January 1, 2015
The study aimed to assess the differences in functional activity, perceived health, and depressive symptoms between individuals with traumatic paraplegia with and without shoulder pain. The results in...
KEY FINDING: Shoulder pain was prevalent in 30% of patients with traumatic paraplegia.
Neural Regeneration Research, 2016 • February 1, 2016
The study used the SmartCage system to monitor early neurobehavioral changes in mice following traumatic brain injury (TBI). It focused on detecting changes in locomotor activity, sleep patterns, and ...
KEY FINDING: Spontaneous activities, including travelled distance and rearing up counts, were significantly decreased in mice receiving CCI at 1 and 2 days after injury, which was strongly correlated with neurological score and tissue damage.
eNeuro, 2017 • August 11, 2017
The study demonstrates that stress and GCs enhance the sprouting and regenerative growth of adult sensory axons, both in vitro and in vivo, highlighting their role as modifiers of neuronal plasticity....
KEY FINDING: DRG sensory neurons express significantly higher levels of glucocorticoid receptors (GRs) compared to brain regions like the hippocampus.
Translational Psychiatry, 2020 • July 15, 2020
The study investigated neuroinflammatory alterations in high trait anxiety using a mouse model (HAB). Results showed increased microglial density and activity in the hippocampus of HAB mice, particula...
KEY FINDING: HAB mice exhibited enhanced density and average cell area of Iba1+ microglia in the dentate gyrus (DG) of the hippocampus compared to NAB controls.
Neural Regeneration Research, 2021 • March 1, 2021
This study investigates the antidepressant effects of solid lipid nanoparticles loaded with curcumin and dexanabinol in a mouse model of major depressive disorder. The results demonstrate that the nan...
KEY FINDING: Solid lipid nanoparticles loaded with curcumin and dexanabinol increased the mRNA and protein expression levels of mature neuronal markers (NeuN, MAP2, Tuj1) in wild-type mice.
Journal of Clinical Medicine, 2020 • December 18, 2020
The study aimed to identify cellular phenotypes in ADHD patient-derived cellular models from carriers of rare copy number variants (CNVs) in the PARK2 locus. Human-derived fibroblasts (HDF) and human-...
KEY FINDING: Changes were found in PARK2 gene and protein expression in PARK2 CNV deletion and duplication carriers with ADHD compared to controls.
Exp Neurol, 2009 • June 1, 2009
This study presents a straight alley version of the BBB locomotor scale for assessing hindlimb motor function in rats after spinal cord injury. The method involves training rats to ambulate in a rewar...
KEY FINDING: BBB scores in the open field and straight alley were highly correlated (r=0.90), validating the straight alley for locomotor assessment.
Exp Neurol, 2009 • November 1, 2009
The Forelimb Locomotor Assessment Scale (FLAS) is introduced to assess forelimb use during locomotion in rats with cervical spinal cord injuries, focusing on movements, coordination, and compensatory ...
KEY FINDING: Recovery of shoulder and elbow joint movement occurred rapidly within 1–7 days post-injury, whereas recovery of wrist joint movement was slower and more variable.