Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 11-20 of 730 results
PLoS ONE, 2011 • November 11, 2011
This study investigates the roles of Nogo receptors NgR1 and NgR2 in the regulation of CD4 T helper responses and CNS repair during experimental autoimmune encephalomyelitis (EAE). The researchers fou...
KEY FINDING: Genetic deletion of NgR1 and NgR2 does not promote functional recovery during EAE.
Cell. Mol. Life Sci., 2012 • May 1, 2012
This study characterizes the morphology and function of leech blood cells, highlighting their involvement in both peripheral immunity and CNS neural repair. The research demonstrates the presence of a...
KEY FINDING: Leeches possess a unique type of blood cell that participates in various immune processes, including antibacterial and antiparasitic defense mechanisms.
PLoS ONE, 2011 • December 21, 2011
This study demonstrates that the glial scar matrix serves as a necessary scaffold, skewing monocytes towards the resolving phenotype, characterized by the production of the anti-inflammatory cytokine ...
KEY FINDING: The glial scar matrix CSPG skews infiltrating monocytes towards a resolving, anti-inflammatory phenotype.
Journal of Neuroinflammation, 2012 • March 15, 2012
This study investigates the role of ADAMTS-4, a proteoglycan-degrading enzyme, in promoting functional recovery after spinal cord injury (SCI). The research demonstrates that ADAMTS-4 can degrade CSPG...
KEY FINDING: ADAMTS-4 degrades endogenous CSPGs like brevican, neurocan, and phosphacan, reversing their inhibition of neurite outgrowth in vitro.
Journal of Cerebral Blood Flow & Metabolism, 2012 • May 2, 2012
This review discusses the principles of neuroinflammation, focusing on the role of microglia and common neurologic disease mechanisms. It also highlights the molecular targets currently used and explo...
KEY FINDING: Microglial activation, a key component of neuroinflammation, can be imaged using TSPO-targeting tracers in various neurological diseases.
Journal of Neuroinflammation, 2012 • May 7, 2012
This study investigates the role of IFNγ in synaptic plasticity and nerve regeneration following peripheral nerve injury in mice. The researchers compared wild-type mice with IFNγ−/− mutant mice after...
KEY FINDING: IFNγ−/− mutant mice showed decreased expression of MHC I and β2-microglobulin mRNA in the lesioned spinal cord segment.
Brain and Behavior, 2012 • January 3, 2012
This study examined Gpnmb expression in the CNS of adult rats under normal and inflammatory conditions, finding Gpnmb mRNA expression in several brain regions and the spinal cord. Immunohistochemical ...
KEY FINDING: Gpnmb mRNA is expressed in the cerebrum, cerebellum, brain stem, and spinal cord of normal adult rats.
PLoS ONE, 2012 • May 22, 2012
This study investigated the gene expression differences between wild-type and EphA4 knockout mice following spinal cord injury to understand the mechanisms underlying functional recovery. Microarray a...
KEY FINDING: EphA4 knockout mice show altered expression of genes related to inflammation following spinal cord injury, specifically an attenuated expression of inflammatory genes.
PLoS ONE, 2012 • August 13, 2012
This study investigates the potential neuroprotective effects of G-CSF on synaptic elements related to spinal alpha-motoneurons following sciatic nerve axotomy in MDX mice, an animal model for Duchenn...
KEY FINDING: G-CSF treatment led to a greater preservation of synaptic inputs after injury in MDX mice compared with untreated and placebo groups.
Stem Cells, 2012 • November 1, 2012
This study demonstrates that allogeneic NPCs are rejected following transplantation into the inflamed CNS of JHMV-infected mice due to T cell-mediated immune responses. The research highlights that al...
KEY FINDING: Allogeneic NPCs are antigenic and induce a delayed-type hypersensitivity (DTH) response, indicating T cell involvement.