Administration of Tamoxifen Can Regulate Changes in Gene Expression during the Acute Phase of Traumatic Spinal Cord Injury

This study investigates the molecular mechanisms behind spinal cord injury (SCI) and explores tamoxifen (TMX) as a potential therapy. The research aims to identify changes in gene expression during the acute phase of SCI and how TMX affects these changes. The study used a rat model, dividing the animals into groups with and without SCI, and with and without TMX treatment. Gene expression analysis was performed to observe the differences between these groups. The results revealed that SCI causes differential expression of many genes related to the inflammatory response. Tamoxifen appears to regulate some of these gene expression changes, particularly in Ccr2 and Mmp12.

• 1
  SCI induces differential expression of 708 genes, with enriched pathways related to the SCI pathway and inflammatory response.
• 2
  TMX treatment results in only 30 differentially expressed genes in SCI rats compared to untreated SCI rats, with no pathways significantly enriched.
• 3
  TMX seems to regulate gene expression changes in Ccr2 and Mmp12, both of which are involved in the inflammatory response.