Browse the latest research summaries in the field of gastroenterology for spinal cord injury patients and caregivers.
Showing 121-130 of 136 results
Annals of Rehabilitation Medicine, 2013 • August 1, 2013
This study aimed to evaluate the usefulness of plain abdominal radiography for assessing bowel dysfunction in patients with spinal cord injury (SCI). The study found significant correlations between c...
KEY FINDING: There were statistically significant correlations between the total CTT and constipation score, and Starreveld and Leech scores.
Frontiers in Cellular Neuroscience, 2022 • May 4, 2022
This study investigated the therapeutic potential of ursolic acid (UA) in treating spinal cord injury (SCI) in mice, focusing on its impact on gut microbiota and metabolic changes. The research demons...
KEY FINDING: UA treatment increased body weight and soleus muscle weight of SCI mice, suggesting improved motor function.
Frontiers in Cellular Neuroscience, 2022 • August 22, 2022
This study found that stress-induced visceral hypersensitivity is linked to downregulated 5-HT1ARs, which in turn enhances ACC theta oscillations. Tandospirone (TDS) was found to alleviate both viscer...
KEY FINDING: Tandospirone (TDS) ameliorated visceral hypersensitivity and anxiety-like behavior induced by water avoidance stress.
Disease Markers, 2022 • October 4, 2022
This work provides a systems perspective to study the relationship between Chinese medicines and diseases. The therapeutic efficacy of XCHD on HF was the sum of multitarget and multi-approach effects fro...
KEY FINDING: 164 potential active compounds from XCHD were screened to act on 95 HF-related targets.
Microbiology Spectrum, 2023 • September 28, 2023
This study uses bibliometric analysis to summarize research trends and hotspots in the field of gut microbiota and the immune microenvironment from 1976 to 2022, using data from the Web of Science Cor...
KEY FINDING: The annual number of publications related to gut microbiota and the immune microenvironment has increased gradually, reflecting the growing interest and development in this field.
Nutrients, 2023 • September 27, 2023
This study investigates the impact of recombinant Interleukin-13 (rIL-13) treatment on gut microbiota composition and functional recovery in mice after spinal cord injury (SCI). The research found tha...
KEY FINDING: Hemisection SCI disturbs the homeostatic microbiota composition.
Frontiers in Microbiology, 2023 • October 20, 2023
This study demonstrates that DCM induces sexually dimorphic gut dysbiosis in mice, with distinct changes in the gut microbiota composition between male and female mice. The study found that DCM is ass...
KEY FINDING: DCM induces gut dysbiosis in mice, and the dysbiosis is sexually dimorphic, with more pronounced changes in male mice compared to females.
CNS Neurosci Ther, 2024 • January 7, 2024
This study investigated the role of EphB2 in the basolateral amygdala (BLA) in the induction and maintenance of visceral hypersensitivity induced by water avoidance stress (WAS) in rats. The findings ...
KEY FINDING: EphB2 expression was increased in the BLA of rats subjected to water avoidance stress (WAS), indicating its involvement in stress-induced visceral hypersensitivity.
Nature Communications, 2024 • December 8, 2024
The study identifies SCM-198 as a potential therapeutic agent for advanced acute liver failure (ALF). SCM-198 demonstrates a remarkable 100% survival rate in murine ALF models, even when administered ...
KEY FINDING: SCM-198 treatment resulted in a 100% survival rate in murine ALF models, even when administered 24 hours after ALF was established.
Journal of Translational Medicine, 2025 • February 11, 2025
This study investigated the effects of fecal microbiota transplantation (FMT) on motor function recovery in a spinal cord injury (SCI) mouse model. The results demonstrated that FMT restored gut micro...
KEY FINDING: FMT significantly improved motor function recovery in SCI mice compared to those treated with antibiotics alone, as shown by BMS scoring, inclined plane test, and footprint analysis.