Browse the latest research summaries in the field of endocrinology for spinal cord injury patients and caregivers.
Showing 151-160 of 217 results
Curr Phys Med Rehabil Rep., 2016 • September 1, 2016
Spinal cord injury (SCI) induced changes in neurological function have significant impact on the metabolism and subsequent metabolic-related disease risk in injured individuals. Although alterations i...
KEY FINDING: High-level spinal cord injuries are associated with lower glucose tolerance, greater insulin resistance, and impaired lipid profiles compared to lower-level injuries.
Neural Regeneration Research, 2017 • December 1, 2017
This review explores techniques for quantifying intermuscular (IMAT) and intramuscular (IntraMAT) adipose tissue using MRI, highlighting inconsistencies in past studies. It compares the Otsu and Midpo...
KEY FINDING: Significant differences exist between the Midpoint and Otsu methods in quantifying intramuscular adipose tissue (%IntraMAT) in the knee extensor muscle group.
The Journal of Spinal Cord Medicine, 2019 • January 1, 2019
This study investigated the prevalence of metabolic syndrome in veterans with spinal cord injury (SCI) using modified International Diabetes Federation (IDF) criteria. The results indicated a high pre...
KEY FINDING: Over 57% of the veterans assessed were determined to have metabolic syndrome by modified IDF criteria, including 76.7% with BMI ≥22 kg/m2.
Physiol Rep, 2018 • January 1, 2018
This study elucidates the mechanisms by which nandrolone stimulates the differentiation of myogenic lineage cells, focusing on the roles of MyoD and Numb. The research demonstrates that androgens stim...
KEY FINDING: Nandrolone increases both MyoD mRNA and protein expression in C2C12 myoblasts, indicating an upregulation of MyoD production.
The Journal of Spinal Cord Medicine, 2019 • July 1, 2019
This study investigated the influence of sex on adipose tissue distribution and its relationship with inflammatory adipokines and cardiometabolic profiles in individuals with motor complete spinal cor...
KEY FINDING: Male participants with SCI had significantly greater visceral adipose tissue (VAT) volume and VAT:SAT ratio compared to females.
Spinal Cord, 2018 • September 1, 2018
The study demonstrated that adiponectin is closely related to body composition and metabolic profile in persons with SCI The links between adiponectin levels and the size of paralyzed muscle suggest p...
KEY FINDING: Adiponectin was negatively related to both total and regional fat mass and positively related to lean mass and muscle mass.
International Journal of Molecular Sciences, 2018 • June 7, 2018
SCI leads to muscle loss and impaired mitochondrial function, partly due to increased FOXO signaling and reduced PGC-1α/β expression. Testosterone promotes muscle anabolism and anticatabolic effects, ...
KEY FINDING: Low testosterone levels are common after SCI and may exacerbate muscle loss and neuromuscular impairment.
PLoS ONE, 2018 • June 27, 2018
This study assessed the association between circulating adipo-myokines and lean mass in 205 men with chronic SCI, finding a significant positive association between lean mass and leptin, independent o...
KEY FINDING: There was a significant positive association between lean mass and leptin in men with SCI that was independent of fat.
Physiol Rep, 2018 • August 1, 2018
This pilot study compared the effects of an 8-week high-protein diet versus a combined exercise regimen on metabolic health in individuals with long-standing spinal cord injury (SCI). Both the high-pr...
KEY FINDING: Fasting plasma glucose levels decreased in the combined exercise group compared to the high-protein diet group.
Physiol Rep, 2018 • September 1, 2018
This study investigates the effects of myostatin on insulin action and glucose uptake in C2C12 muscle cells. Myostatin, known for its role in inhibiting muscle growth, is shown to impair insulin-stimu...
KEY FINDING: Myostatin significantly reduced basal and insulin-induced IRS-1 tyrosine phosphorylation, expression and activation of PI3K, associated with diminished AKT phosphorylation and elevated GSK3b phosphorylation.