Browse the latest research summaries in the field of endocrinology for spinal cord injury patients and caregivers.
Showing 131-140 of 217 results
Spinal Cord, 2017 • July 1, 2017
This study aimed to determine if low testosterone levels in men with spinal cord injury (SCI) are due to primary testicular dysfunction by testing their response to varying doses of human chorionic go...
KEY FINDING: The average gonadal response in the SCI and AB groups to each dose of hCG was not significantly different in the hypogonadal or eugonadal subjects.
BMJ Open, 2017 • July 4, 2017
This study investigates the effects of evoked resistance training (RT) combined with testosterone replacement therapy (TRT) on body composition and metabolic profiles in men with chronic, motor comple...
KEY FINDING: The trial will investigate the use of surface neuromuscular electrical stimulation-induced resistance training (NMES-RT) to restore muscle size after spinal cord injury (SCI).
Spinal Cord Series and Cases, 2016 • April 7, 2016
This retrospective case series evaluated the effectiveness of high-amplitude penile vibratory stimulation (PVS) for sperm retrieval in anejaculatory Asian men with spinal cord injury (SCI). The study ...
KEY FINDING: The overall ejaculatory success rate using high amplitude PVS was 46.15%.
J Neurotrauma, 2017 • November 1, 2017
This study aimed to determine if testosterone (TE) prevents bone deficits post-spinal cord injury (SCI) and if finasteride (FIN) is required for TE-induced skeletal preservation. The study found that ...
KEY FINDING: TE+FIN prevented the chronic cancellous bone deficits and LABC muscle loss in SCI animals without inducing prostate enlargement.
The Journal of Spinal Cord Medicine, 2017 • March 1, 2017
A recent study showed weight loss in SCI patients, but the author argues that BMI alone is insufficient to assess health in this population due to changes in body composition. Body composition, partic...
KEY FINDING: Persons categorized as overweight or obese at baseline experienced overall weight loss over 1 year, while those initially characterized as underweight or of normal weight appeared to gain weight.
Dev Neurobiol, 2017 • October 1, 2017
This study explores the role of estrogen signaling in exercise-mediated enhancement of motoneuron participation in axon regeneration after peripheral nerve injury in mice. The results indicate that bo...
KEY FINDING: Treadmill training and estradiol administration both increased motoneuron participation in axon regeneration.
Spinal Cord, 2018 • March 1, 2018
This study aimed to determine the optimal GnRH dose to identify hypothalamic-pituitary-gonadal axis dysfunction in men with SCI by comparing gonadotropin responses to different GnRH doses (10, 50, 100...
KEY FINDING: Lower doses of GnRH did not improve the ability to identify clinical dysfunction of the hypothalamic-pituitary-gonadal axis.
J. Biol. Chem., 2017 • May 2, 2017
This study investigates how muscle-released products interact with bone cells to influence their function, focusing on myostatin's role in muscle-bone interaction. Myostatin directly targets osteocyte...
KEY FINDING: Myostatin increases the expression of SOST, DKK1, and RANKL in osteocytes, which are important regulators in bone remodeling.
JOURNAL OF NEUROTRAUMA, 2010 • March 1, 2010
This study demonstrates that delayed, post-injury administration of 17b-estradiol reduces secondary damage and promotes functional recovery after SCI. Eliminating testicular-derived androgens increase...
KEY FINDING: Post-SCI administration of 17b-estradiol improves hindlimb locomotion.
The Journal of Spinal Cord Medicine, 2011 • January 1, 2011
This cross-sectional study assessed dyslipidemia management in men with chronic SCI according to NCEP guidelines, revealing suboptimal treatment and control rates, particularly in intermediate- and hi...
KEY FINDING: Dyslipidemia was present in 39.5% of the men with chronic SCI.