Browse the latest research summaries in the field of bioinformatics for spinal cord injury patients and caregivers.
Showing 211-220 of 334 results
The EMBO Journal, 2021 • September 24, 2021
The study reveals a conserved developmental map of the human telencephalon, highlighting the temporal cell fate transition from neuroectoderm (NE) to radial glial cells (RGs) to intermediate progenito...
KEY FINDING: Dorsal and ventral telencephalons share common developmental programs during neurogenesis, following a conserved trajectory from radial glial cells (RGs) to intermediate progenitor cells (IPCs_div) and then to early neuroblasts (eNBs).
Molecular Nutrition & Food Research, 2021 • October 28, 2021
This study investigated the role of diet and gut microbiota in cognitive decline (CD) using a 12-year prospective study design involving two separate sample sets from Bordeaux and Dijon. The findings ...
KEY FINDING: Metabolites derived from cocoa, coffee, mushrooms, and red wine are associated with reduced cognitive decline.
Front. Cell Dev. Biol., 2021 • October 11, 2021
This study used bioinformatics analysis to identify key eRNAs involved in spinal cord injury (SCI). The analysis revealed a regulatory network of transcription factors, eRNAs, target genes, immune ce...
KEY FINDING: Identified 21 DETFs, 24 DEeRNAs, and 829 DETGs in SCI patients compared to healthy controls.
Bioactive Materials, 2022 • January 1, 2022
This study utilizes single-cell RNA sequencing to investigate the molecular mechanisms underlying MSC-mediated bone regeneration in different osteogenic microenvironments, specifically focusing on hyd...
KEY FINDING: HA scaffolds induce bone formation through a process similar to endochondral ossification, activating TGF-β, PTHrP, and BMP signaling pathways sequentially.
Brain Sci, 2021 • November 30, 2021
The study used RNA-sequencing to identify differentially expressed genes in fetal spinal cords from rats with retinoic acid-induced spina bifida at E15, E17, and E20. The results suggest common alterat...
KEY FINDING: The study found approximately 3000, 1000, and 300 genes were differentially expressed at E15, E17, and E20, respectively, compared to control groups.
International Journal of Medical Sciences, 2022 • January 1, 2022
This study investigates the role of immune cells and genes in Alzheimer's Disease (AD) by analyzing transcriptomic data from the prefrontal cortex of AD patients and healthy controls. The analysis rev...
KEY FINDING: Immune infiltration in the prefrontal cortex of AD patients differs from healthy samples, highlighting alterations in the brain's immune environment during AD.
BMC Genomics, 2022 • January 3, 2022
This study investigated DNA methylation changes in regenerative and non-regenerative regions of the Xenopus CNS after injury. The study found that DNA methylation patterns differ significantly between...
KEY FINDING: DNA from regenerative CNS (tadpole hindbrain, frog eye) was less methylated than non-regenerative CNS (frog hindbrain).
Alzheimer’s Research & Therapy, 2022 • January 4, 2022
This study demonstrates that the early onset of CD may possibly be preceded by profound alterations in fatty acid metabolism and related metabolic pathways, which are in turn modulated by ApoE-ε4 and ...
KEY FINDING: Increased circulating levels of free fatty acids, acyl-carnitines and pantothenic acid were found among those participants who had greater odds of cognitive decline over a 12-year follow-up.
Adv Healthc Mater, 2022 • May 1, 2022
The study addresses the thermal instability of ChABC, which limits its therapeutic use for CNS injuries. Machine learning was used to design copolymers that stabilize ChABC in aCSF, with promising res...
KEY FINDING: Active machine learning identified copolymers that significantly improved ChABC's thermal stability.
Signal Transduction and Targeted Therapy, 2022 • January 9, 2022
This study provides a detailed map of cellular and molecular changes in the mouse spinal cord after crush injury, utilizing single-cell transcriptomics to identify dynamic responses in various cell ty...
KEY FINDING: Identified 12 different major cell types and their pathological changes after spinal cord crush injury, including the infiltration of stromal cells, neutrophils, and lymphocytes at distinct times post-injury.