Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 4,101-4,110 of 12,052 results
Cell Prolif., 2022 • September 1, 2022
This review summarizes the pathological processes and mechanisms underlying inflammation, cell death and glial scar formation in secondary injury. In the acute phase of SCI, surgical intervention and ...
KEY FINDING: Early apoptosis and autophagy after TSCI protect against injury; prolonged inflammation leads to accumulation of pro-inflammatory factors and excessive apoptosis, aggravating TSCI.
Annals of Translational Medicine, 2022 • September 1, 2022
This study investigates the effects of decellularization on the microenvironment of injured spinal cords and its potential to promote neurite outgrowth. The researchers found that decellularization re...
KEY FINDING: The expression of ECM components (collagen type I and IV, fibronectin, and laminin) increased with SCI progression, peaking at 14 days post-injury.
Neurospine, 2022 • September 1, 2022
This review aims to describe the involvement of ECM components in the remodeling process of spinal cord injury (SCI) and intervertebral disc degeneration (IVDD). SCI leads to damage to the intact ECM...
KEY FINDING: ECM components demonstrate both regenerative and degenerative potential in the central nervous system.
Neurospine, 2022 • September 1, 2022
This study aimed to identify differentially expressed genes (DEGs) by transcriptome analysis to elucidate a potential mechanism by which governor vessel electroacupuncture (GV-EA) promotes neuronal su...
KEY FINDING: GV-EA treatment regulated the expression of 173 mRNA, 260 lncRNA, and 153 circRNA genes altered by SCI.
J. Biol. Chem., 2022 • August 31, 2022
This study investigates the role of Triad1 in promoting astrocyte-dependent neurite outgrowth to accelerate recovery after spinal cord injury (SCI) by inhibiting MDM2-mediated PTN ubiquitination. The ...
KEY FINDING: Triad1 overexpression promoted PTN protein levels, NGF expression, BDNF expression, astrocyte and neuronal viability, and neurite outgrowth but suppressed astrocyte apoptosis.
Journal of Clinical Orthopaedics and Trauma, 2022 • August 31, 2022
DTI is a non-invasive MRI technique that assesses spinal cord microstructure by tracking water molecule movement, revealing damage through changes in anisotropy and diffusivity. DTI parameters like FA...
KEY FINDING: Reduced FA is consistently observed at injury sites due to disruption of anisotropy, indicating damage to the white matter tracts.
Diagnostics, 2022 • August 31, 2022
The study developed a diagnostic support tool for DCM using grip strength and GRT measurements from DCM surgery patients and healthy controls. GRT and grip strength showed good diagnostic accuracy ind...
KEY FINDING: The diagnostic support tool, combining GRT and grip strength, showed an overall sensitivity of 88.2% and a specificity of 78.1% in diagnosing DCM.
Ann Rehabil Med, 2022 • August 31, 2022
The study aimed to evaluate the usefulness of DTI and tractography in predicting outcomes after traumatic cervical SCI, comparing pre- and post-operative data. Preoperative DTI and tractography showed...
KEY FINDING: The failure rate of DTI image analysis was significantly higher in the postop group compared to the preop group.
Int. J. Environ. Res. Public Health, 2022 • August 31, 2022
This study investigated the factors affecting depression in family caregivers of spinal-cord-injury patients. Data were collected on caregiver depression, patient and caregiver characteristics, physic...
KEY FINDING: Caregivers of patients who were not economically active reported higher levels of depression.
Frontiers in Rehabilitation Sciences, 2022 • August 31, 2022
The study investigates the barriers and supports for children in kindergarten through fifth grade returning to school after a spinal cord injury or disorder (SCI/D). Survey results indicated that chil...
KEY FINDING: A significant number of children were placed in integrated education after their SCI/D, despite not experiencing cognitive decline.