Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,921-11,930 of 12,052 results
Cytotechnology, 2006 • December 5, 2006
This study introduces an optimized method for preparing highly pure astrocyte cultures from rat spinal cord. The method involves modifications to the isolation procedures and cultivation conditions, i...
KEY FINDING: The optimized method consistently produced astrocyte cultures with greater than 99% purity, as confirmed by immunofluorescence staining against GFAP and OX-42.
J Neurobiol, 2006 • December 1, 2006
This study demonstrates that the mechanism of axon regeneration undergoes a developmental switch between E7 and E14 from strict dependence on F-actin to a greater dependence on microtubule polymerizat...
KEY FINDING: Early embryonic (E7) sensory axons strictly require F-actin for axon maintenance and regeneration, whereas later embryonic (E14) axons can extend even in the absence of F-actin.
The Journal of Neuroscience, 2006 • November 29, 2006
This study demonstrates that H-reflex conditioning can correct a physiologically defined locomotor abnormality caused by an anatomically defined spinal cord lesion in rats. The results suggest that re...
KEY FINDING: Midthoracic transection of the right lateral column of the spinal cord produced a persistent asymmetry in the muscle activity underlying treadmill locomotion.
The Journal of Neuroscience, 2006 • November 22, 2006
This study investigates the role of Nogo-A and its receptor NgR1 in limiting axonal growth in the adult CNS, using a pyramidotomy model to assess CST axon sprouting in nogo-abatg/atg and ngr1-/- mice....
KEY FINDING: In nogo-abatg/atg and ngr1-/- mice, there is significant growth of CST axons into denervated cervical gray matter following pyramidotomy.
Eur Spine J, 2007 • November 14, 2006
The study presents a rare case of cervical intramedullary brucellar granuloma (IBG) in a 35-year-old female, who had a history of Brucella meningitis and improper medication intake. The patient presen...
KEY FINDING: This case represents the first reported instance of intramedullary granuloma of the cervical spine caused by Brucella. Prior cases involved the thoracic spine or conus medullaris.
J Appl Physiol, 2006 • November 1, 2006
The study compared torque feedback-controlled (FDBCK) electrical stimulation with classic open-loop constant-frequency (CONST) stimulation to improve muscle performance in chronically paralyzed muscle...
KEY FINDING: In fresh muscle, feedback-controlled stimulation offered minimal advantage in maintaining peak torque or mean torque over constant stimulation.
J Neurotrauma, 2006 • November 1, 2006
This study introduces the Louisville Swimming Scale (LSS) as a novel assessment tool for evaluating hindlimb function in rats following spinal cord injury, focusing on swimming ability. The LSS evalua...
KEY FINDING: The Louisville Swimming Scale (LSS) is a sensitive and reliable method for determining swimming ability and the improvement in hindlimb function after spinal cord injury.
The Journal of Neuroscience, 2006 • October 25, 2006
The study aimed to understand the mechanisms of OEC migration and axonal guidance after SCI by injecting lamina propria OECs near SCI sites. The findings indicate that OECs form cell tracts that displ...
KEY FINDING: OECs do not exhibit significant migratory properties when grafted to the spinal cord after SCI.
The Journal of Neuroscience, 2006 • October 18, 2006
This study investigates the effects of ChABC treatment on promoting plasticity within the spinal cord after injury. The key finding is that ChABC induces de novo sprouting in degenerating white-matter...
KEY FINDING: ChABC promotes sprouting of injured (corticospinal) and intact (serotonergic) descending projections after a cervical dorsal column injury.
The Journal of Neuroscience, 2006 • October 11, 2006
This study examined the effects of different robotic training algorithms on locomotor recovery in spinal cord-injured mice. The algorithms included a fixed trajectory and two assist-as-needed (AAN) ap...
KEY FINDING: Mice trained with the AAN window paradigm showed the highest level of recovery, as measured by the number, consistency, and periodicity of steps during the testing sessions.