Browse the latest research summaries in the field of rehabilitation for spinal cord injury patients and caregivers.
Showing 3,001-3,010 of 3,020 results
Cell, 2018 • July 26, 2018
The study demonstrates that chronic KCC2 activation, either pharmacologically or through gene delivery, reactivates dormant spared circuitry and results in persistent hindlimb stepping in mice with st...
KEY FINDING: CLP290, a KCC2 agonist, restores consistent stepping ability in paralyzed mice with staggered spinal cord lesions, but not in mice with complete spinal cord transection.
Nature Communications, 2018 • August 2, 2018
This study investigated the role of oligodendrocyte remyelination in locomotor recovery after spinal cord injury (SCI) by selectively ablating it in transgenic mice. The researchers found that while M...
KEY FINDING: MYRF expression in PDGFRα-positive cell-derived oligodendrocytes is indispensable for myelin regeneration following contusive SCI.
Frontiers in Neurology, 2018 • November 20, 2018
The study investigates the potential of prior regular exercise to modify the effects of pharmacological treatments, specifically glatiramer acetate (GA) and dimethyl fumarate (DMF), in a murine model ...
KEY FINDING: Exercised-GA treated animals demonstrated decreased astrocytic response in the spinal dorsal horn with an improvement in the paw print pressure.
Scientific Reports, 2019 • May 8, 2019
The study evaluates the effect of photobiomodulation (PBM) using a Multiwave Locked System (MLS) laser with 808 nm and 905 nm wavelengths on spinal cord injury (SCI) recovery in rats. Results indicate...
KEY FINDING: Laser treatment significantly improved locomotor functions of rats after spinal cord injury from the first week following lesioning, compared to controls.
CNS Neuroscience & Therapeutics, 2020 • February 1, 2020
This study investigated whether adding BDNF to anti-Nogo-A antibody treatment could enhance functional recovery after spinal cord injury (SCI) in adult macaque monkeys. Previous research has shown tha...
KEY FINDING: Monkeys treated with anti-Nogo-A antibody alone showed functional recovery of manual dexterity performances close to prelesion ones, irrespective of lesion size.
Journal of Clinical Medicine, 2020 • June 3, 2020
This study explores the application of laser therapy in medicine and dentistry, focusing on its mechanism of action on cells, especially stem cells, and repair mechanisms. Laser irradiation induces a ...
KEY FINDING: Photobiomodulation enhances tissue repair by modulating cell behavior, promoting cell proliferation, and enhancing stem cell differentiation.
International Journal of Molecular Sciences, 2020 • August 1, 2020
This study demonstrates that noradrenergic innervation plays a significant role in locomotor recovery in paraplegic rats after intraspinal grafting of embryonic brainstem tissue, complementing the wel...
KEY FINDING: Morphological analysis revealed the presence of tyrosine hydroxylase positive (NA) neurons in addition to 5-HT neurons in the host spinal cords of grafted rats.
Cureus, 2020 • October 27, 2020
ESWT shows promise in increasing bone mineral density in osteoporosis patients and reducing pain associated with heterotopic ossification after spinal cord injury. ESWT can improve range of motion and...
KEY FINDING: ESWT may increase bone mineral density (BMD) in patients with osteoporosis, potentially prolonging the asymptomatic period of vertebral body compressive changes and radicular symptoms.
J Lasers Med Sci, 2020 • October 3, 2020
The present study illustrates that LLL therapy has positive effects on improving functional recovery and regulating the inflammatory function in the SCI. According to the results of previous studies, ...
KEY FINDING: LLL therapy was able to reduce inflammation and also attenuate neuronal damage after spinal cord damage.
Phil. Trans. R. Soc. B, 2006 • August 4, 2006
This review discusses some aspects of plasticity of connections after spinal injury in adult animal models as a basis for functional recovery of locomotion. It is concluded that recovery is partly due...
KEY FINDING: Locomotor training can modify the excitability of reflex pathways and complex neural circuits within the spinal cord.