Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 2,251-2,260 of 2,298 results
Stem Cells, 2010 • January 1, 2010
This study demonstrates that human embryonic stem cell-derived oligodendrocyte progenitor cells (hESC-derived OPCs) can provide at-level benefit to cervical spinal cord injury (SCI). Transplantation o...
KEY FINDING: Transplanted hESC-derived OPCs survived, localized to the injury site, and differentiated into mature oligodendrocytes.
Journal of Biological Chemistry, 2010 • January 8, 2010
The study identifies FM19G11 as a novel HIF inhibitor that selectively targets HIF proteins without significant cytotoxicity. FM19G11 promotes oligodendrocyte differentiation under hypoxic conditions ...
KEY FINDING: FM19G11 inhibits HIF1α and HIF2α protein accumulation in human tumor cell lines and stem cells from rodents and humans.
JBC Papers in Press, 2009 • November 9, 2009
This study investigates the role of neuronal Nogo-A in axonal regeneration, finding that its expression increases after axonal injury and exposure to myelin. The research demonstrates that disrupting ...
KEY FINDING: Neuronal Nogo-A expression increases after axonal injury and exposure to myelin.
J Neurosci Res, 2010 • May 1, 2010
The study investigates the potential of neural restricted precursors (NRP) and glial restricted precursors (GRP) to generate specific neuronal phenotypes in the injured spinal cord and extend axons to...
KEY FINDING: NRP/GRP grafts can generate glutamatergic and GABAergic neurons in the injured spinal cord, which are essential for repairing local interneuron circuits damaged by SCI.
J Neuropathol Exp Neurol, 2009 • December 1, 2009
This study investigated the therapeutic potential of olfactory bulb ensheathing glia (OB-OEG) for repairing chronic spinal cord injuries (SCI) in rats. Rats with complete SCI received OB-OEG transplan...
KEY FINDING: OB-OEG transplantation in rats with chronic SCI led to progressive improvement in motor function.
JoVE, 2009 • January 1, 2009
One of the goals of our research is to promote axon regeneration to restore connectivity across the lesion site. Importantly, the peripheral nerve grafting approach is effective in promoting regenerat...
KEY FINDING: Ascending and descending spinal axons will enter the graft, grow in a relatively straight line parallel to the length of the graft and extend to the distal end of the graft at a rate of approximately 1 mm per day.
The Journal of Neuroscience, 2009 • November 25, 2009
This study demonstrates that administering ChABC to a distal graft interface allows for functional axonal regeneration by chronically injured neurons. The researchers combined grafting of a peripheral...
KEY FINDING: ChABC treatment digests CSPGs within a chronic scar, which promotes behavioral recovery after chronic SCI.
The Journal of Neuroscience, 2009 • November 25, 2009
This study evaluated the therapeutic potential of human mesenchymal stem cells (hMSCs) and brain-derived neurotrophic factor-secreting hMSCs (BDNF-hMSCs) in a rat model of spinal cord injury (SCI). Th...
KEY FINDING: Transplantation of BDNF-hMSCs resulted in improved locomotor recovery compared to hMSC transplantation alone.
The Journal of Neuroscience, 2009 • December 2, 2009
This study demonstrates that adult zebrafish possess a subpopulation of ependymoradial glial cells that retain transcription factor expression of the embryonic pMN zone. It provides evidence that thes...
KEY FINDING: Adult zebrafish spinal cord contains ependymoradial glial cells that retain transcription factor expression of the embryonic pMN zone.
The Journal of Neuroscience, 2010 • January 13, 2010
The study identified daidzein, a soy isoflavone, as a potential therapeutic agent for CNS injuries due to its ability to induce Arg1 expression and promote axonal regeneration. Daidzein's mechanism of...
KEY FINDING: Daidzein was identified as a transcriptional inducer of Arg1 through a chemical screen of clinically approved drugs.