Browse the latest research summaries in the field of neurorehabilitation for spinal cord injury patients and caregivers.
Showing 331-340 of 344 results
Neural Regeneration Research, 2013 • September 1, 2013
This study aimed to investigate the effect of treadmill step training on functional recovery and neural plasticity in rats with moderate spinal cord contusion. The results showed that treadmill traini...
KEY FINDING: Treadmill training significantly improved spontaneous motor activity in rats with incomplete spinal cord injury, as measured by Basso, Beattie and Bresnahan scores.
Crit Rev Phys Rehabil Med, 2013 • January 1, 2013
This review summarizes key predictors of post-stroke rehabilitation outcomes, highlighting the strengths and weaknesses of many studies to provide recommendations for providers of post-stroke rehabili...
KEY FINDING: Younger age is consistently associated with better outcomes after stroke rehabilitation.
Bone Jt Open, 2022 • May 1, 2022
This review provides a concise outline of the advances made in the care of patients and to the quality of life after a traumatic spinal cord injury (SCI) over the last century. Despite these improveme...
KEY FINDING: There remains limited commercial interest in developing innovative therapies for SCI due to multiple mechanisms that drive delayed injury and a low incidence of injuries each year worldwide.
Front. Med. Technol., 2024 • May 15, 2024
We hypothesized a reduced SICI preceding movement in patients with SCI compared with healthy participants; hence, less increase of cortical excitability due to a constant hyper excitability that is in...
KEY FINDING: There were neither significant differences between healthy participants and the patients nor between the different patient groups.
Int. J. Mol. Sci., 2025 • January 19, 2025
This review discusses the principles and potential mechanisms of rTMS for treating SCI, including promoting the reconstruction of damaged circuits, activating cortical reorganization, modulating moton...
KEY FINDING: rTMS can promote activity-dependent regeneration of corticospinal tract (CST) axonal projections and the recruitment of propriospinal neurons and circuits.
Neural Regeneration Research, 2019 • June 1, 2019
This case study examined motor output reorganization in a patient with unihemispheric cortical atrophy due to Rasmussen encephalitis, focusing on ipsilateral corticospinal pathways using transcranial ...
KEY FINDING: The patient with Rasmussen encephalitis showed higher median amplitudes of ipsilateral motor evoked potentials (MEPs) in the first dorsal interosseous and wrist extensors muscles compared to healthy controls.
Molecular Therapy, 2017 • December 1, 2017
This study investigates a combinatorial approach to promote axonal regeneration after cervical spinal cord injury (SCI). The approach involves transplanting a peripheral nerve graft (PNG), expressing ...
KEY FINDING: Expressing caRheb in neurons post-SCI results in more axons regenerating across a ChABC-treated distal graft interface into caudal spinal cord than either treatment alone.
The Journal of Neuroscience, 2019 • June 12, 2019
This study investigates the molecular changes in the spinal cord after cortical stroke in mice, focusing on factors that influence the reinnervation process by contralesional corticospinal neurons. Th...
KEY FINDING: The spinal transcriptome after cortical stroke is characterized by two phases: an early inflammatory phase and a late tissue repair phase with upregulated genes related to neurite outgrowth.
Frontiers in Neurology, 2020 • March 10, 2020
The study evaluated single and combined treatments—pre-degenerated peripheral nerve grafts (PPN), bone marrow stromal cells (BMSCs), and chondroitinase ABC (ChABC)—on rats with chronic spinal cord inj...
KEY FINDING: Combined treatment groups (PPN + BMSCs and PPN + BMSCs + ChABC) showed significant axonal regrowth, indicated by increased GAP-43 and MAP-1B expression in axonal fibers.
Neural Regen Res, 2021 • September 22, 2020
This study investigates the combination of epidural electrical stimulation (EES) with ex vivo triple gene therapy for spinal cord injury (SCI) in rat models. The gene therapy involves transplanting ge...
KEY FINDING: Rats subjected to the combined treatment showed a limited functional improvement of the knee joint and high preservation of muscle fiber area.