Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 81-90 of 5,401 results
Journal of Biomedicine and Biotechnology, 2011 • August 17, 2011
This study investigates CNPase expression in olfactory ensheathing cells (OECs) using CNPase-eGFP transgenic mice, finding that OECs in the olfactory bulb express CNPase, a marker for myelinating cell...
KEY FINDING: OECs in the outer nerve layer of the olfactory bulb express CNPase.
Brazilian Journal of Medical and Biological Research, 2012 • January 16, 2012
This study evaluated the efficacy of mononuclear cells from human umbilical cord blood in promoting functional recovery after spinal cord injury in rats. Cells were transplanted either directly into t...
KEY FINDING: Transplantation of mononuclear cells from human umbilical cord blood promoted functional recovery in rats with spinal cord injury.
Cell Tissue Res, 2012 • December 22, 2011
This review discusses the potential of deoxyribozymes as therapeutic agents for central nervous system (CNS) trauma, particularly spinal cord injury (SCI), in conjunction with bioinformatics approache...
KEY FINDING: Deoxyribozymes, also called DNA enzymes or DNAzymes, are single-stranded DNA molecules developed using systematic evolution of ligands by exponential enrichment (SELEX).
PLoS ONE, 2011 • December 21, 2011
This study demonstrates that the glial scar matrix serves as a necessary scaffold, skewing monocytes towards the resolving phenotype, characterized by the production of the anti-inflammatory cytokine ...
KEY FINDING: The glial scar matrix CSPG skews infiltrating monocytes towards a resolving, anti-inflammatory phenotype.
Exp Neurol, 2012 • May 1, 2012
This study compares the efficacy of peripheral nerve conditioning lesions to cAMP elevations on central sensory axonal regeneration when administered either before or after cervical spinal cord lesion...
KEY FINDING: Conditioning lesions are more effective than cAMP elevations on central axonal regeneration, especially when combined with cellular grafts and viral neurotrophin delivery.
Brain, 2012 • February 1, 2012
This study investigates the therapeutic plasticity of neural stem/precursor cells (NPCs) after focal implantation in a severely contused spinal cord. The findings identify a precise window of opportun...
KEY FINDING: Subacute transplantation of neural stem/precursor cells (NPCs) led to significant recovery of locomotor functions in mice with spinal cord injury.
Gene Ther., 2012 • September 1, 2012
The study introduces a novel viral strategy for targeting protein expression specifically to the axonal compartment of neurons. This approach utilizes a modified Sindbis virus containing an RNA genome...
KEY FINDING: Adult neurons contain ribosomes in distal axons, particularly at the nodes of Ranvier, suggesting that local protein synthesis is possible in mature axons.
Frontiers in Molecular Neuroscience, 2012 • January 3, 2012
Following an acute central nervous system (CNS) injury, axonal regeneration and functional recovery are extremely limited. This is due to an extrinsic inhibitory growth environment and the lack of int...
KEY FINDING: RARβ2 lentiviral infection of adult rat DRGs induced axonal growth and functional recovery of injured sensory neurons into the dorsal root entry zone (DREZ) following dorsal root lesion.
Drug Discov Today, 2012 • August 1, 2012
This review provides an overview of traumatic CNS injuries and discusses emerging pharmacological options, highlighting therapies that modulate mTOR signaling. The mTOR pathway plays an important role...
KEY FINDING: Activation of the mTOR pathway can reduce neuronal death and promote repair and regeneration in the CNS.
Eur J Neurosci, 2012 • February 1, 2012
Adult zebrafish can regenerate spinal cords, unlike mammals. This study investigates the role of cysteine and glycine-rich protein 1 (CRP1) in this process. Microarray analysis identified CRP1 as upre...
KEY FINDING: CRP1 (csrp1a) is upregulated in neurons after spinal cord injury (SCI) in zebrafish. The upregulation occurs in regenerative nuclei like NMLF, IMRF, and SRF.