Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 61-70 of 5,401 results
Frontiers in Molecular Neuroscience, 2011 • September 23, 2011
This mini-review discusses the potential of deoxyribozymes as a therapeutic approach for central nervous system (CNS) disorders, particularly spinal cord injuries (SCIs). Deoxyribozymes are catalytic ...
KEY FINDING: Deoxyribozymes can be designed to cleave specific mRNA targets, preventing protein translation and potentially altering disease pathways.
Comp Biochem Physiol B Biochem Mol Biol, 2012 • February 1, 2012
This study isolated and characterized two forms of the rem2 gene, designated O. mykiss rem2a and rem2b, from the adult rainbow trout. The presence of Rem2 isoforms in rainbow trout is not unexpected a...
KEY FINDING: The study describes the first isolation of two alternate forms of Rem2 in a non-mammalian species, the rainbow trout, and presents the complete characterization of the cDNAs for both rem2 genes. Also, the tissue specificity of both rem2 genes and their expression profiles across major regions of the CNS were compared.
Cell Death and Disease, 2011 • October 13, 2011
The study provides a detailed anatomical description of serotonergic projections and 5-HT1A receptor distribution in the human spinal cord at thoracic and lumbar levels. The findings reveal similariti...
KEY FINDING: Serotonergic profiles are present in the ventral horn, surrounding motoneurons, and also contact their presumptive dendrites at the lumbar level.
The Journal of Neuroscience, 2011 • October 12, 2011
This study identifies a novel signaling mechanism in axonal guidance, where the chemoattractant Netrin-1 and its receptor DCC couple with SNARE proteins (Sytx1 and TI-VAMP) to regulate membrane turnov...
KEY FINDING: The Netrin-1 receptor DCC forms a protein complex with the t-SNARE protein Syntaxin-1 (Sytx1) in a Netrin-1-dependent manner.
Frontiers in Molecular Neuroscience, 2011 • September 29, 2011
This study investigated changes in gene expression in the sensorimotor cortex of rats following spinal cord injury (SCI) and treatment with an anti-scarring treatment (AST). Microarray analysis reveal...
KEY FINDING: Spinal cord injury induces significant changes in cortical gene expression as early as 1 day post-injury, with a peak at 21 days.
Crit Care Med, 2012 • February 1, 2012
Post-SCI, early systemic hypothermia provided significant neuroprotection weeks after injury via improved sensory electrophysiological signals in rats. This was accompanied by higher motor behavioral ...
KEY FINDING: Hypothermia group showed significantly higher SSEP amplitudes post-injury compared to controls.
J. Cell. Mol. Med., 2012 • July 1, 2012
This study investigated the therapeutic potential of in utero mesenchymal stem cell (MSCs) transplantation in rat foetuses with spina bifida aperta. The results suggest that prenatal MSC transplantati...
KEY FINDING: Transplanted MSCs survived in the defective spinal cord of rat foetuses with induced neural tube defects.
Journal of Biomedical Optics, 2011 • October 4, 2011
This study investigates myelin integrity in mice with relapsing experimental autoimmune encephalomyelitis (EAE) using coherent anti-Stokes Raman scattering (CARS) microscopy. The research demonstrates...
KEY FINDING: Paranodal myelin retraction is an early event in relapsing experimental autoimmune encephalomyelitis (EAE), occurring at the onset of the disease and at the borders of acute demyelinating lesions.
Journal of Neuroinflammation, 2011 • November 13, 2011
This study examines the role of NG2, a proteoglycan expressed by OPCs, pericytes, and macrophages/microglia, in spinal cord demyelination and remyelination using wild type and NG2 null mice. Results s...
KEY FINDING: The initial volume of spinal cord demyelination in wild type mice is twice as large as in NG2 null mice, suggesting NG2 influences the initial damage phase.
PLoS ONE, 2011 • November 11, 2011
This study investigates the roles of Nogo receptors NgR1 and NgR2 in the regulation of CD4 T helper responses and CNS repair during experimental autoimmune encephalomyelitis (EAE). The researchers fou...
KEY FINDING: Genetic deletion of NgR1 and NgR2 does not promote functional recovery during EAE.