Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 21-30 of 5,401 results
J Comp Neurol, 2011 • June 1, 2011
This study characterized zebrafish myelin protein zero (P0) using novel antibodies, determining its biochemical properties, subcellular localization, and expression patterns in the central nervous sys...
KEY FINDING: Zebrafish P0 is a 23.5 kDa glycoprotein containing a 3 kDa N-linked carbohydrate moiety.
JBC, 2011 • May 20, 2011
This study profiles phosphoprotein signaling networks in neurites during growth and retraction to identify key regulatory mechanisms. Microporous filter method was used to purify neurites, followed by...
KEY FINDING: Identified over 4000 non-redundant phosphorylation sites from 1883 proteins, mapping to signaling pathways controlling kinase/phosphatase networks, cytoskeleton remodeling, and axon/dendrite specification.
The Journal of Neuroscience, 2011 • April 6, 2011
This study systematically investigates the impact of prolonged motoneuron axotomy, distal nerve stump denervation, and muscle denervation on functional recovery after peripheral nerve repair using a r...
KEY FINDING: Chronic denervation of the distal nerve stump plays a crucial role in reducing nerve regeneration after peripheral nerve injury.
Nature Communications, 2021 • August 13, 2021
This study reveals how physical activity regulates the creation of new nerve cells in adult zebrafish spinal cords through the interaction of two neurotransmitters: acetylcholine (ACh) and GABA. The st...
KEY FINDING: Physical activity induces animal growth and proliferation in the spinal cord.
Neuroscience, 2011 • July 14, 2011
This study investigates the role of microRNAs (miRNAs) in spinal cord injury (SCI) by comparing miRNA expression in contused and sham rat spinal cords at 4 and 14 days post-injury. The researchers ide...
KEY FINDING: Several miRNAs, including miR124, miR129, and miR1, were significantly down-regulated following spinal cord contusion, while miR21 was significantly induced.
PNAS, 2011 • May 10, 2011
The study demonstrates that Smad1-dependent BMP signaling is developmentally regulated and governs axonal growth potential in DRG neurons. Reactivation of Smad1 in adult DRG neurons, achieved through ...
KEY FINDING: Smad1-dependent BMP signaling is developmentally regulated and governs axonal growth in dorsal root ganglion (DRG) neurons.
Gene Ther., 2012 • January 1, 2012
This study systematically compared seven AAV serotypes and an integration-deficient lentiviral vector for their ability to transduce corticospinal neurons (CSNs) following intracortical injection in r...
KEY FINDING: AAV1 was the most effective serotype for transducing cortical and CSNs, with GFP expression detectable in fibers projecting through the dorsal corticospinal tract (dCST) of the cervical spinal cord.
Cell Tissue Res., 2011 • June 1, 2011
This study investigates the cellular mechanisms of spinal cord regeneration in fresh-water turtles, focusing on cell proliferation and cytoarchitectural changes following injury. The research demonstr...
KEY FINDING: Spinal cord transection induces a significant increase in cell proliferation around the lesion epicenter in turtles.
Frontiers in Neurology, 2011 • April 27, 2011
This study compared nerve repair using ethyl cyanoacrylate (ECA) adhesive versus conventional sutures in rats after sciatic nerve transection, focusing on the selectivity of reinnervation of the later...
KEY FINDING: The study found that after nerve repair with both ECA and sutures, the motoneuron pool was markedly disorganized, with motoneurons scattered throughout a larger volume of the spinal cord gray matter.
J Neurosci Methods, 2011 • August 15, 2011
This study demonstrates the efficacy of a lentiviral vector (Chase/LV) encoding chondroitinase AC (Chase) in vitro and in vivo to degrade CSPGs. Chase/LV-infected cells showed sustained expression of ...
KEY FINDING: Neural precursor cells infected with Chase/LV expressed the GFP reporter, and the expression increased over time in culture, indicating successful transduction and expression of the transgene.