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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Genetics Research

Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.

Showing 41-50 of 1,773 results

NeurologyGenetics

Fine-tuning oligodendrocyte development by microRNAs

Frontiers in Neuroscience, 2012 • February 6, 2012

This review highlights the role of microRNAs (miRNAs) in fine-tuning oligodendrocyte development, a process crucial for myelination in the central nervous system. The review discusses how specific miR...

KEY FINDING: MicroRNAs (miRNAs) play a critical role in oligodendrocyte development, including cell proliferation, differentiation, and myelin formation.

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Regenerative MedicineNeurologyGenetics

Optimization of adult sensory neuron electroporation to study mechanisms of neurite growth

Frontiers in Molecular Neuroscience, 2012 • February 8, 2012

This study optimized electroporation parameters for adult rat DRG neurons using the Lonza 4D-Nucleofector system to achieve high transfection efficiencies. The optimized protocol reduced the required ...

KEY FINDING: The Lonza 4D-Nucleofector X-unit system achieved transfection efficiencies of 39–42%, significantly higher than previous methods for adult DRG neurons.

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NeurologyGeneticsBiomedical

Electric Field-controlled Directed Migration of Neural Progenitor Cells in 2D and 3D Environments

J. Vis. Exp., 2012 • February 16, 2012

The spinal cordslice is an ideal recipient tissue for studying NPC ex vivo behaviours, post-transplantation, because the cytoarchitectonic tissue organization is well preserved within these cultures T...

KEY FINDING: NPCs showed highly directed cell migration towards the cathode when exposed to a range of physiological EFs.

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NeurologyGenetics

Generation and Nuclear Translocation of Sumoylated Transmembrane Fragment of Cell Adhesion Molecule L1

JBC, 2012 • May 18, 2012

The neural cell adhesion molecule L1 plays crucial roles during development of the nervous system, such as neuronal migration and survival, axon outgrowth and fasciculation, and myelination, but it is...

KEY FINDING: L1 stimulation leads to the generation of a 70-kDa transmembrane fragment that is translocated to the nucleus.

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Spinal Cord InjuryNeurologyGenetics

PlexinA4 Distribution in the Adult Rat Spinal Cord and Dorsal Root Ganglia

J Chem Neuroanat, 2012 • May 1, 2012

This study describes the spatial distribution of PlexinA4 in the rat spinal cord, as well as its co-expression with markers of motor neurons throughout the adult spinal cord. Evidence of PlexinA4 expr...

KEY FINDING: PlexinA4 immunolabeling was found in neurons in both dorsal and ventral horns of the spinal cord, with more PlexinA4 positive neurons in the ventral horn.

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Regenerative MedicineGenetics

In vivo Electroporation of Morpholinos into the Regenerating Adult Zebrafish Tail Fin

Journal of Visualized Experiments, 2012 • March 29, 2012

The zebrafish fin is a relatively simple appendage that is easily manipulated to study multiple stages in epimorphic regeneration. We developed a reverse genetic technique to quickly and easily test t...

KEY FINDING: The described protocol permits conditional protein knockdown to examine the role of specific proteins during regenerative fin outgrowth.

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Spinal Cord InjuryNeurologyGenetics

Krüppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract

PNAS, 2012 • May 8, 2012

The study addresses the failure of axon regeneration in the CNS due to a developmental decline in the intrinsic ability of neurons to extend axons, focusing on the transcription factor KLF7. To overco...

KEY FINDING: VP16-KLF7 effectively promotes neurite outgrowth and displays enhanced expression compared to wild-type KLF7 in dissociated neurons.

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Regenerative MedicineImmunologyGenetics

Decreased MHC I expression in IFN gamma mutant mice alters synaptic elimination in the spinal cord after peripheral injury

Journal of Neuroinflammation, 2012 • May 7, 2012

This study investigates the role of IFNγ in synaptic plasticity and nerve regeneration following peripheral nerve injury in mice. The researchers compared wild-type mice with IFNγ−/− mutant mice after...

KEY FINDING: IFNγ−/− mutant mice showed decreased expression of MHC I and β2-microglobulin mRNA in the lesioned spinal cord segment.

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ImmunologyNeurologyGenetics

Expression and immunolocalization of Gpnmb, a glioma-associated glycoprotein, in normal and inflamed central nervous systems of adult rats

Brain and Behavior, 2012 • January 3, 2012

This study examined Gpnmb expression in the CNS of adult rats under normal and inflammatory conditions, finding Gpnmb mRNA expression in several brain regions and the spinal cord. Immunohistochemical ...

KEY FINDING: Gpnmb mRNA is expressed in the cerebrum, cerebellum, brain stem, and spinal cord of normal adult rats.

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Regenerative MedicineNeurologyGenetics

Kindlin-1 Enhances Axon Growth on Inhibitory Chondroitin Sulfate Proteoglycans and Promotes Sensory Axon Regeneration

The Journal of Neuroscience, 2012 • May 23, 2012

The study investigates the roles of kindlin-1 and kindlin-2 in axon growth and regeneration, focusing on integrin activation and signaling. Kindlin-1 overexpression enhances integrin activation, promo...

KEY FINDING: Kindlin-2 is present in the nervous system, whereas Kindlin-1 is not naturally expressed.

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